Comparative analysis of risk-based cleanup levels and associated remediation costs using linearized multistage model (cancer slope factor) vs. threshold approach (reference dose) for three chlorinated alkenes
- Geraghty and Miller, Inc., Andover, MA (United States)
- Geraghty and Miller, Inc., Langhorne, PA (United States)
The chlorinated alkenes 1,1-dichloroethene (1,1-DCE), tetrachloroethene (PCE), and trichloroethene (TCE) are common environmental contaminants found in soil and groundwater at hazardous waste sites. Recent assessment of data from epidemiology and mechanistic studies indicates that although exposure to 1,1-DCE, PCE, and TCE causes tumor formation in rodents, it is unlikely that these chemicals are carcinogenic to humans. Nevertheless, many state and federal agencies continue to regulate these compounds as carcinogens through the use of the linearized multistage model and resulting cancer slope factor (CSF). The available data indicate that 1,1-DCE, PCE, and TCE should be assessed using a threshold (i.e., reference dose [RfD]) approach rather than a CSF. This paper summarizes the available metabolic, toxicologic, and epidemiologic data that question the use of the linear multistage model (and CSF) for extrapolation from rodents to humans. A comparative analysis of potential risk-based cleanup goals (RBGs) for these three compounds in soil is presented for a hazardous waste site. Goals were calculated using the USEPA CSFs and using a threshold (i.e., RfD) approach. Costs associated with remediation activities required to meet each set of these cleanup goals are presented and compared.
- OSTI ID:
- 250890
- Report Number(s):
- CONF-9507204-; TRN: IM9629%%203
- Resource Relation:
- Conference: 27. Mid-Atlantic industrial waste conference, Bethlehem, PA (United States), 9-12 Jul 1995; Other Information: PBD: 1995; Related Information: Is Part Of Hazardous and industrial wastes: Proceedings of the twenty-seventh Mid-Atlantic industrial waste conference; Sengupta, A.K. [ed.] [Lehigh Univ., Bethlehem, PA (United States)]; PB: 973 p.
- Country of Publication:
- United States
- Language:
- English
Similar Records
Dechlorination of PCE and TCE to ethene using an anaerobic microbial consortium
Reductive dechlorination of chlorinated ethenes and 1,2-dichloroethane by Dehalococcoides ethenogenes'' 195