Reversible alkyne insertion in the benzannulation reaction of Fischer carbene complexes with alkynes
Conference
·
OSTI ID:250116
- Univ. of Chicago, IL (United States)
The benzannulation reaction of Fischer carbene complexes with alkynes to give phenols is highly regioselective with terminal alkynes, and reasonably regioselective with internal alkynes. This has been attributed to steric factors in intermediates, where one form is favored due to close contact between the R substituent and a cis-CO ligand. Whether alkyne insertion is kinetically or thermodynamically controlled has not been determined. The authors now have evidence from regioselectivity studies that alkyne insertion into the metal-carbon bond is reversible. Implications of these results and further mechanistic considerations will be presented.
- OSTI ID:
- 250116
- Report Number(s):
- CONF-9508100--
- Country of Publication:
- United States
- Language:
- English
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