Effect of radioiodine therapy on pulmonary alveolar-capillary membrane integrity

Journal Article · Mon May 01 04:00:00 EDT 1995 · Journal of Nuclear Medicine

OSTI ID:250039

Samuel, A M; Unnikrishnan, T P; Baghel, N S ^[1]

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1. Bhabha Atomic Research Center, Bombay (India); and others

The effects of large doses of radioiodine on the pulmonary alveolar-capillary membrane using {sup 99m}Tc-DTPA clearance as an index of pulmonary damage in subjects with pulmonary metastases of differentiated thyroid carcinoma were studied. Technetium-99m-DTPA radioaerosols were generated by a dry aerosol generator. Data were acquired and analyzed for clearance half-time from the lungs with a scintillation camera. The study was carried out on 35 thyroid cancer patients with pulmonary metastases and on 32 patients without metastases; the results were compared to those of a control group comprising 52 subjects. The radiation dose delivered to the lungs from the therapeutic dose was calculated using MIRD methodology. Cumulative radioiodine doses varied form 5.9 to 44.2 GBq (158-1194 mCi). The half-time clearance of {sup 99m}Tc-DTPA was comparable in both patient groups and was not related to the total administered radioiodine dosage or to the radiation dose delivered to the lungs. No changes were observed for periods up to 5 yr after receiving the last/radioiodine dosage. Seven patients followed at regular intervals from 6 mo to 2 yr did not show abnormal {sup 99m}Tc-DTPA clearance values. One patient did show low {sup 99m}Tc-DTPA clearance half-time values, which were symptomatic radiation pneumoritis. She had received a total dose of 34 GBq (922 mCi) over a 4-yr period. The incidence of pulmonary damage resulting from radioiodine therapy for lung metastases of differentiated thyroid cancer is negligible, as evidenced by the normal pulmonary clearance half-time of {sup 99m}Tc-DTPA aerosols. 22 refs., 2 figs., 4 tabs.

• OSTI ID: 250039
• Journal Information: Journal of Nuclear Medicine, Journal Name: Journal of Nuclear Medicine Journal Issue: 5 Vol. 36; ISSN 0161-5505; ISSN JNMEAQ
• Country of Publication: United States
• Language: English

Related Subjects

56 BIOLOGY AND MEDICINE
APPLIED STUDIES
BIOLOGICAL RADIATION EFFECTS
CARCINOMAS
IODINE 131
IODINE COMPOUNDS
LUNGS
RADIONUCLIDE KINETICS
RADIOTHERAPY
THYROID