Comparative metabolism of o -toluidine by the abalone (Haliotis rufescens) and flatfish (Platichthys stellatus)

Journal Article · Mon Mar 31 23:00:00 EST 1986 · Environmental Toxicology and Chemistry

DOI:https://doi.org/10.1002/etc.5620050408· OSTI ID:2496814

Knezovich, John P.; Crosby, Donald G.

Abstract

Abalone and flatfish excreted 2-nitrosotoluene and N-acetyl-o-toluidine, respectively, as the only biotransformation products of o-toluidine. The elimination of o-toluidine over a 4-h period was high for both species (greater than 80%), but the total extent of metabolism was low (less than 2%). A Sprague-Dawley rat was used to compare the metabolic pathways typically found in mammals with those found in the marine organisms. Metabolism of o-toluidine by the rat was extensive (greater than 95%), and ring-hydroxylated conjugates were rapidly eliminated.

The metabolic capabilities of terrestrial vertebrates are more extensive than those found in aquatic organisms and may reflect the greater need for water conservation in terrestrial species. Aquatic organisms such as molluscs may not be at a disadvantage, however, because many such compounds are likely to be eliminated by passive diffusion.

• Sponsoring Organization: USDOE
• OSTI ID: 2496814
• Journal Information: Environmental Toxicology and Chemistry, Journal Name: Environmental Toxicology and Chemistry Journal Issue: 4 Vol. 5; ISSN 0730-7268
• Publisher: Oxford University Press
• Country of Publication: United States
• Language: English