Stable, Dispersible Surface-Enhanced Raman Scattering Substrate Capable of Detecting Molecules Bound to Silica-Immobilized Ligands

Poston, Pete E.; Harris, Joel M.

doi:10.1366/000370210793335061

Stable, Dispersible Surface-Enhanced Raman Scattering Substrate Capable of Detecting Molecules Bound to Silica-Immobilized Ligands

Journal Article · Mon Nov 01 00:00:00 EDT 2010 · Applied Spectroscopy

DOI:https://doi.org/10.1366/000370210793335061· OSTI ID:2480873

Poston, Pete E. ^[1]; Harris, Joel M. ^[1]

University of Utah, Salt Lake City, UT (United States)

A stable surface-enhanced Raman scattering (SERS) substrate is developed through immobilization of gold sols onto aminated silica beads. The plasmon resonance is established by spacing of gold sols on the bead surface and remains stable over extended periods of time due to the large number of amine groups that provide stable anchoring of gold to the surface. Unlike planar supports, this substrate can be dispersed in a sample, providing high surface area for detection and efficient transport of analytes to its surface. This substrate can be used to detect the binding of a molecule to ligands on the silica surface, which avoids the stability limitations of thiol-bound ligands on gold. Chemical modification of the amine groups on the silica surface with benzoic anhydride could be readily detected in Raman scattering enhanced by the neighboring gold sols, with nearly the same sensitivity as benzylthiol bound directly to the gold surfaces. Furthermore, this result suggests future work involving the immobilization of other ligands through the residual amine groups to the silica, which could be used to selectively attract target analytes to the SERS-active surface.

View Accepted Manuscript (DOE)

Research Organization:: University of Utah, Salt Lake City, UT (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES). Chemical Sciences, Geosciences & Biosciences Division (CSGB)

Grant/Contract Number:: FG03-93ER14333

OSTI ID:: 2480873

Journal Information:: Applied Spectroscopy, Journal Name: Applied Spectroscopy Journal Issue: 11 Vol. 64; ISSN 0003-7028

Publisher:: Society for Applied SpectroscopyCopyright Statement

Country of Publication:: United States

Language:: English

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Surface-enhanced Raman spectroscopy (SERS)
gold sols

Stable, Dispersible Surface-Enhanced Raman Scattering Substrate Capable of Detecting Molecules Bound to Silica-Immobilized Ligands

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