Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho

Dias, Gisele Pereira; Murphy, Tytus; Stangl, Doris; Ahmet, Selda; Morisse, Benjamin; Nix, Alina; Aimone, Lindsey J.; Aimone, James B.; Kuro-O, Makoto; Gage, Fred H.; Thuret, Sandrine

doi:10.1038/s41380-021-01102-4

Intermittent fasting enhances long-term memory consolidation, adult hippocampal neurogenesis, and expression of longevity gene Klotho

Journal Article · Tue May 25 00:00:00 EDT 2021 · Molecular Psychiatry

DOI:https://doi.org/10.1038/s41380-021-01102-4· OSTI ID:2471752

Dias, Gisele Pereira ^[1]; Murphy, Tytus ^[1]; Stangl, Doris ^[1]; Ahmet, Selda ^[1]; Morisse, Benjamin ^[1]; Nix, Alina ^[1]; Aimone, Lindsey J. ^[2]; ^[3]; ^[4]; ^[2]; ^[5]

King's College, London (United Kingdom)
Salk Institute for Biological Studies, La Jolla, CA (United States)
Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)
Jichi Medical University, Tochigi (Japan)
King's College, London (United Kingdom); Technische Universität Dresden (Germany)

Daily calorie restriction (CR) and intermittent fasting (IF) enhance longevity and cognition but the effects and mechanisms that differentiate these two paradigms are unknown. We examined whether IF in the form of every-other-day feeding enhances cognition and adult hippocampal neurogenesis (AHN) when compared to a matched 10% daily CR intake and ad libitum conditions. After 3 months under IF, female C57BL6 mice exhibited improved long-term memory retention. IF increased the number of BrdU-labeled cells and neuroblasts in the hippocampus, and microarray analysis revealed that the longevity gene Klotho (Kl) was upregulated in the hippocampus by IF only. Furthermore, we found that downregulating Kl in human hippocampal progenitor cells led to decreased neurogenesis, whereas Kl overexpression increased neurogenesis. Finally, histological analysis of Kl knockout mice brains revealed that Kl is required for AHN, particularly in the dorsal hippocampus. These data suggest that IF is superior to 10% CR in enhancing memory and identifies Kl as a novel candidate molecule that regulates the effects of IF on cognition likely via AHN enhancement.

View Accepted Manuscript (DOE)

Research Organization:: Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA); Medical Research Council (MRC); National Council for Scientific and Technological Development (CNPq); Japan Agency for Medical Research and Development (AMED)

Grant/Contract Number:: NA0003525

OSTI ID:: 2471752

Journal Information:: Molecular Psychiatry, Journal Name: Molecular Psychiatry Journal Issue: 11 Vol. 26; ISSN 1359-4184

Publisher:: SpringerCopyright Statement

Country of Publication:: United States

Language:: English

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