Relationships between Habitual Polyphenol Consumption and Gut Microbiota in the INCLD Health Cohort

Vita, Alexandra Adorno; Roberts, Kristen M.; Gundersen, Anders; Farris, Yuliya; Zwickey, Heather; Bradley, Ryan; Weir, Tiffany L.

doi:10.3390/nu16060773

Relationships between Habitual Polyphenol Consumption and Gut Microbiota in the INCLD Health Cohort

Journal Article · Fri Mar 08 00:00:00 EST 2024 · Nutrients

DOI:https://doi.org/10.3390/nu16060773· OSTI ID:2471547

^[1]; Roberts, Kristen M. ^[2]; Gundersen, Anders ^[3]; Farris, Yuliya ^[4]; ^[3]; Bradley, Ryan ^[5]; ^[6]

National University of Natural Medicine, Portland, OR (United States); Colorado State University, Fort Collins, CO (United States)
The Ohio State University, Columbus, OH (United States)
National University of Natural Medicine, Portland, OR (United States)
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
National University of Natural Medicine, Portland, OR (United States); University of California, San Diego, CA (United States)
Colorado State University, Fort Collins, CO (United States)

While polyphenol consumption is often associated with an increased abundance of beneficial microbes and decreased opportunistic pathogens, these relationships are not completely described for polyphenols consumed via habitual diet, including culinary herb and spice consumption. This analysis of the International Cohort on Lifestyle Determinants of Health (INCLD Health) cohort uses a dietary questionnaire and 16s microbiome data to examine relationships between habitual polyphenol consumption and gut microbiota in healthy adults (n = 96). In this exploratory analysis, microbial taxa, but not diversity measures, differed by levels of dietary polyphenol consumption. Taxa identified as exploratory biomarkers of daily polyphenol consumption (mg/day) included Lactobacillus, Bacteroides, Enterococcus, Eubacterium ventriosum group, Ruminococcus torques group, and Sutterella. Taxa identified as exploratory biomarkers of the frequency of polyphenol-weighted herb and spice use included Lachnospiraceae UCG-001, Lachnospiraceae UCG-004, Methanobrevibacter, Lachnoclostridium, and Lachnotalea. Several of the differentiating taxa carry out activities important for human health, although out of these taxa, those with previously described pro-inflammatory qualities in certain contexts displayed inverse relationships with polyphenol consumption. Our results suggest that higher quantities of habitual polyphenol consumption may support an intestinal environment where opportunistic and pro-inflammatory bacteria are represented in a lower relative abundance compared to those with less potentially virulent qualities.

View Accepted Manuscript (DOE)

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: National Institutes of Health (NIH); USDOE

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 2471547

Journal Information:: Nutrients, Journal Name: Nutrients Journal Issue: 6 Vol. 16; ISSN 2072-6643

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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GPCR-mediated effects of fatty acids and bile acids on glucose homeostasis Oteng, Antwi-Boasiako; Liu, Liu Frontiers in Endocrinology, Vol. 14 https://doi.org/10.3389/fendo.2023.1206063	journal	July 2023
Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases Parada Venegas, Daniela; De la Fuente, Marjorie K.; Landskron, Glauben Frontiers in Immunology, Vol. 10 https://doi.org/10.3389/fimmu.2019.00277	journal	March 2019
Bile acids in immunity: Bidirectional mediators between the host and the microbiota Godlewska, Urszula; Bulanda, Edyta; Wypych, Tomasz P. Frontiers in Immunology, Vol. 13 https://doi.org/10.3389/fimmu.2022.949033	journal	August 2022
Mucosal Prevalence and Interactions with the Epithelium Indicate Commensalism of Sutterella spp. Hiippala, Kaisa; Kainulainen, Veera; Kalliomäki, Marko Frontiers in Microbiology, Vol. 7 https://doi.org/10.3389/fmicb.2016.01706	journal	October 2016
Surface (S) Layer Proteins of Lactobacillus acidophilus Block Virus Infection via DC-SIGN Interaction Prado Acosta, Mariano; Geoghegan, Eileen M.; Lepenies, Bernd Frontiers in Microbiology, Vol. 10 https://doi.org/10.3389/fmicb.2019.00810	journal	April 2019
Circulating Levels of the Short-Chain Fatty Acid Acetate Mediate the Effect of the Gut Microbiome on Visceral Fat Nogal, Ana; Louca, Panayiotis; Zhang, Xinyuan Frontiers in Microbiology, Vol. 12 https://doi.org/10.3389/fmicb.2021.711359	journal	July 2021
Effects of several flavonoids on human gut microbiota and its metabolism by in vitro simulated fermentation Pan, Lixia; Ye, Hangyu; Pi, Xionge Frontiers in Microbiology, Vol. 14 https://doi.org/10.3389/fmicb.2023.1092729	journal	February 2023
Cigarette Smoking and Human Gut Microbiota in Healthy Adults: A Systematic Review Antinozzi, Martina; Giffi, Monica; Sini, Nicolò Biomedicines, Vol. 10, Issue 2 https://doi.org/10.3390/biomedicines10020510	journal	February 2022
The Interaction between Flavonoids and Intestinal Microbes: A Review Xiong, Hui-Hui; Lin, Su-Yun; Chen, Ling-Li Foods, Vol. 12, Issue 2 https://doi.org/10.3390/foods12020320	journal	January 2023
The Effect of Psyllium Husk on Intestinal Microbiota in Constipated Patients and Healthy Controls Jalanka, Jonna; Major, Giles; Murray, Kathryn International Journal of Molecular Sciences, Vol. 20, Issue 2 https://doi.org/10.3390/ijms20020433	journal	January 2019
Short-Chain Fatty Acids and Their Association with Signalling Pathways in Inflammation, Glucose and Lipid Metabolism He, Jin; Zhang, Peiwen; Shen, Linyuan International Journal of Molecular Sciences, Vol. 21, Issue 17 https://doi.org/10.3390/ijms21176356	journal	September 2020
Short-Chain Fatty Acid Receptors and Cardiovascular Function Lymperopoulos, Anastasios; Suster, Malka S.; Borges, Jordana I. International Journal of Molecular Sciences, Vol. 23, Issue 6 https://doi.org/10.3390/ijms23063303	journal	March 2022
Gut Microbiota and Cardiovascular Disease: Evidence on the Metabolic and Inflammatory Background of a Complex Relationship Nesci, Antonio; Carnuccio, Claudia; Ruggieri, Vittorio International Journal of Molecular Sciences, Vol. 24, Issue 10 https://doi.org/10.3390/ijms24109087	journal	May 2023
Gut Microbiota and Serum Metabolome in Elite Cross-Country Skiers: A Controlled Study Hintikka, Jukka E.; Munukka, Eveliina; Valtonen, Maarit Metabolites, Vol. 12, Issue 4 https://doi.org/10.3390/metabo12040335	journal	April 2022
Bile Salt Hydrolases: At the Crossroads of Microbiota and Human Health Bourgin, Mélanie; Kriaa, Aicha; Mkaouar, Héla Microorganisms, Vol. 9, Issue 6 https://doi.org/10.3390/microorganisms9061122	journal	May 2021
Consumption of Stilbenes and Flavonoids is Linked to Reduced Risk of Obesity Independently of Fiber Intake Mompeo, Olatz; Spector, Tim D.; Matey Hernandez, Marisa Nutrients, Vol. 12, Issue 6 https://doi.org/10.3390/nu12061871	journal	June 2020
A Polyphenol Enriched Variety of Apple Alters Circulating Immune Cell Gene Expression and Faecal Microbiota Composition in Healthy Adults: A Randomized Controlled Trial Barnett, Matthew P. G.; Young, Wayne; Armstrong, Kelly Nutrients, Vol. 13, Issue 4 https://doi.org/10.3390/nu13041092	journal	March 2021
Associations between Frequency of Culinary Herb Use and Gut Microbiota Vita, Alexandra Adorno; McClure, Ryan; Farris, Yuliya Nutrients, Vol. 14, Issue 9 https://doi.org/10.3390/nu14091981	journal	May 2022
The Effects of Berry Polyphenols on the Gut Microbiota and Blood Pressure: A Systematic Review of Randomized Clinical Trials in Humans Sweeney, Marva; Burns, Gracie; Sturgeon, Nora Nutrients, Vol. 14, Issue 11 https://doi.org/10.3390/nu14112263	journal	May 2022
Interplay between the (Poly)phenol Metabolome, Gut Microbiome, and Cardiovascular Health in Women: A Cross-Sectional Study from the TwinsUK Cohort Li, Yong; Xu, Yifan; Le Roy, Caroline Nutrients, Vol. 15, Issue 8 https://doi.org/10.3390/nu15081900	journal	April 2023
A blend of 3 mushrooms dose-dependently increases butyrate production by the gut microbiota Verhoeven, J.; Keller, D.; Verbruggen, S. Beneficial Microbes, Vol. 12, Issue 6 https://doi.org/10.3920/BM2021.0015	journal	November 2021
Dietary intake of 337 polyphenols in French adults Pérez-Jiménez, Jara; Fezeu, Léopold; Touvier, Mathilde The American Journal of Clinical Nutrition, Vol. 93, Issue 6 https://doi.org/10.3945/ajcn.110.007096	journal	June 2011
Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study—a randomized controlled trial Mastroiacovo, Daniela; Kwik-Uribe, Catherine; Grassi, Davide The American Journal of Clinical Nutrition, Vol. 101, Issue 3 https://doi.org/10.3945/ajcn.114.092189	journal	March 2015
Effects of resveratrol on cerebral blood flow variables and cognitive performance in humans: a double-blind, placebo-controlled, crossover investigation Kennedy, David O.; Wightman, Emma L.; Reay, Jonathon L. The American Journal of Clinical Nutrition, Vol. 91, Issue 6 https://doi.org/10.3945/ajcn.2009.28641	journal	June 2010
Total and Specific Polyphenol Intakes in Midlife Are Associated with Cognitive Function Measured 13 Years Later3 Kesse-Guyot, Emmanuelle; Fezeu, Léopold; Andreeva, Valentina A. The Journal of Nutrition, Vol. 142, Issue 1 https://doi.org/10.3945/jn.111.144428	journal	January 2012
Cocoa Flavanol Intake and Biomarkers for Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Controlled Trials Lin, Xiaochen; Zhang, Isabel; Li, Alina The Journal of Nutrition, Vol. 146, Issue 11 https://doi.org/10.3945/jn.116.237644	journal	November 2016
Archaebiotics: Proposed therapeutic use of archaea to prevent trimethylaminuria and cardiovascular disease Brugère, Jean-François; Borrel, Guillaume; Gaci, Nadia Gut Microbes, Vol. 5, Issue 1 https://doi.org/10.4161/gmic.26749	journal	October 2013
Ellagic acid alleviates adjuvant induced arthritis by modulation of pro- and anti-inflammatory cytokines Allam, Gamal; Mahdi, Emad A.; Alzahrani, Abdullah M. Central European Journal of Immunology, Vol. 4 https://doi.org/10.5114/ceji.2016.65132	journal	January 2016

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60 APPLIED LIFE SCIENCES
Nutrition & Dietetics
culinary herbs and spices
microbiome
phytochemicals
polyphenols

Relationships between Habitual Polyphenol Consumption and Gut Microbiota in the INCLD Health Cohort

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