Interactions of Cells and Biomaterials for Nerve Tissue Engineering: Polymers and Fabrication

Harley-Troxell, Meaghan E.; Steiner, Richard; Advincula, Rigoberto C.; Anderson, David E.; Dhar, Madhu

doi:10.3390/polym15183685

Interactions of Cells and Biomaterials for Nerve Tissue Engineering: Polymers and Fabrication

Journal Article · Thu Sep 07 00:00:00 EDT 2023 · Polymers

DOI:https://doi.org/10.3390/polym15183685· OSTI ID:2471425

^[1]; Steiner, Richard ^[1]; Advincula, Rigoberto C. ^[2]; ^[1]; ^[1]

Univ. of Tennessee, Knoxville, TN (United States)
Univ. of Tennessee, Knoxville, TN (United States); Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States). Center for Nanophase Materials Sciences (CNMS)

Neural injuries affect millions globally, significantly impacting their quality of life. The inability of these injuries to heal, limited ability to regenerate, and the lack of available treatments make regenerative medicine and tissue engineering a promising field of research for developing methods for nerve repair. This review evaluates the use of natural and synthetic polymers, and the fabrication methods applied that influence a cell’s behavior. Methods include cross-linking hydrogels, incorporation of nanoparticles, and 3D printing with and without live cells. The endogenous cells within the injured area and any exogenous cells seeded on the polymer construct play a vital role in regulating healthy neural activity. This review evaluates the body’s local and systemic reactions to the implanted materials. Although numerous variables are involved, many of these materials and methods have exhibited the potential to provide a biomaterial environment that promotes biocompatibility and the regeneration of a physical and functional nerve. Future studies may evaluate advanced methods for modifying material properties and characterizing the tissue–biomaterial interface for clinical applications.

View Accepted Manuscript (DOE)

Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 2471425

Journal Information:: Polymers, Journal Name: Polymers Journal Issue: 18 Vol. 15; ISSN 2073-4360

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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Animal models used to study direct peripheral nerve repair: a systematic review Vela, FranciscoJavier; Martínez-Chacón, Guadalupe; Ballestín, Alberto Neural Regeneration Research, Vol. 15, Issue 3 https://doi.org/10.4103/1673-5374.266068	journal	January 2020
Cytotoxicity Tests for Evaluating Medical Devices: An Alert for the Development of Biotechnology Health Products Vidal, M. N. P.; Granjeiro, J. M. Journal of Biomedical Science and Engineering, Vol. 10, Issue 09 https://doi.org/10.4236/jbise.2017.109033	journal	January 2017
Current Status of Therapeutic Approaches against Peripheral Nerve Injuries: A Detailed Story from Injury to Recovery Hussain, Ghulam; Wang, Jing; Rasul, Azhar International Journal of Biological Sciences, Vol. 16, Issue 1 https://doi.org/10.7150/ijbs.35653	journal	January 2020

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