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Immune correlates of protection by mRNA-1273 vaccine against SARS-CoV-2 in nonhuman primates

Journal Article · · Science
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  1. National Institutes of Health (NIH), Bethesda, MD (United States)
  2. Emory Univ., Atlanta, GA (United States)
  3. Duke Univ., Durham, NC (United States). Medical Center
  4. Moderna Inc., Cambridge, MA (United States)
  5. Bioqual Inc., Rockville, MD (United States)
+ Show Author Affiliations
Immune correlates of protection can be used as surrogate endpoints for vaccine efficacy. Here, nonhuman primates (NHPs) received either no vaccine or doses ranging from 0.3 to 100 μg of the mRNA-1273 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine. mRNA-1273 vaccination elicited circulating and mucosal antibody responses in a dose-dependent manner. Viral replication was significantly reduced in bronchoalveolar lavages and nasal swabs after SARS-CoV-2 challenge in vaccinated animals and most strongly correlated with levels of anti–S antibody and neutralizing activity. Lower antibody levels were needed for reduction of viral replication in the lower airway than in the upper airway. Passive transfer of mRNA-1273–induced immunoglobulin G to naïve hamsters was sufficient to mediate protection. Thus, mRNA-1273 vaccine–induced humoral immune responses are a mechanistic correlate of protection against SARS-CoV-2 in NHPs.
Research Organization:
Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE Office of Science (SC)
Grant/Contract Number:
SC0014664
OSTI ID:
2471339
Journal Information:
Science, Journal Name: Science Journal Issue: 6561 Vol. 373; ISSN 0036-8075
Publisher:
AAASCopyright Statement
Country of Publication:
United States
Language:
English

References (44)

Development of a Rapid Focus Reduction Neutralization Test Assay for Measuring SARS‐CoV‐2 Neutralizing Antibodies journal November 2020
Surrogate endpoints in clinical trials: Definition and operational criteria journal April 1989
Systemic and local immune responses to enhanced-potency inactivated poliovirus vaccine in premature and term infants journal May 1992
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK journal January 2021
Safety and efficacy of an rAd26 and rAd5 vector-based heterologous prime-boost COVID-19 vaccine: an interim analysis of a randomised controlled phase 3 trial in Russia journal February 2021
An interactive web-based dashboard to track COVID-19 in real time journal May 2020
Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing and hospital-based cohort study journal September 2021
Serum sample neutralisation of BBIBP-CorV and ZF2001 vaccines to SARS-CoV-2 501Y.V2 journal July 2021
The Architecture of SARS-CoV-2 Transcriptome journal May 2020
Infection- and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variant journal April 2021
Generation of VSV pseudotypes using recombinant ΔG-VSV for studies on virus entry, identification of entry inhibitors, and immune responses to vaccines journal November 2010
COVID-19 vaccines: where we stand and challenges ahead journal January 2021
SARS-CoV-2 viral load is associated with increased disease severity and mortality journal October 2020
N-protein presents early in blood, dried blood and saliva during asymptomatic and symptomatic SARS-CoV-2 infection journal March 2021
Correlates of protection against SARS-CoV-2 in rhesus macaques journal December 2020
Virological assessment of hospitalized patients with COVID-2019 journal April 2020
Respiratory disease in rhesus macaques inoculated with SARS-CoV-2 journal May 2020
Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques journal July 2020
Sensitivity of infectious SARS-CoV-2 B.1.1.7 and B.1.351 variants to neutralizing antibodies journal March 2021
Immunoglobulin Response in Serum and Secretions after Immunization with Live and Inactivated Poliovaccine and Natural Infection journal October 1968
SARS-CoV-2 Viral Load in Upper Respiratory Specimens of Infected Patients journal March 2020
Neutralizing Activity of BNT162b2-Elicited Serum journal April 2021
Serum Neutralizing Activity Elicited by mRNA-1273 Vaccine journal April 2021
Neutralization of SARS-CoV-2 Variants B.1.429 and B.1.351 journal June 2021
An mRNA Vaccine against SARS-CoV-2 — Preliminary Report journal November 2020
Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates journal October 2020
Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine journal December 2020
Efficacy and Safety of the mRNA-1273 SARS-CoV-2 Vaccine journal February 2021
Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen journal August 2017
Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development journal June 2020
Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses journal May 2018
Mixture models for single-cell assays with applications to vaccine studies journal July 2013
Nomenclature for Immune Correlates of Protection After Vaccination journal March 2012
Mucosal Immune Response to Poliovirus Vaccines in Childhood journal May 1984
Characteristics of the Immune Response to Poliovirus Virion Polypeptides After Immunization with Live or Inactivated Polio Vaccines journal July 1988
Mucosal Immunity Induced by Enhanced-Potency Inactivated and Oral Polio Vaccines journal January 1991
Emergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa posted_content January 2020
Immunogenicity of clinically relevant SARS-CoV-2 vaccines in nonhuman primates and humans journal March 2021
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation journal February 2020
Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model journal April 2020
SARS-CoV-2 infection protects against rechallenge in rhesus macaques journal May 2020
DNA vaccine protection against SARS-CoV-2 in rhesus macaques journal May 2020
Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England journal March 2021
Viridot: An automated virus plaque (immunofocus) counter for the measurement of serological neutralizing responses with application to dengue virus journal October 2018

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