Response to Bovine Viral Diarrhea Virus in Heifers Vaccinated with a Combination of Multivalent Modified Live and Inactivated Viral Vaccines

Falkenberg, Shollie M.; Dassanayake, Rohana P.; Crawford, Lauren; Davila, Kaitlyn Sarlo; Boggiatto, Paola

doi:10.3390/v15030703

Response to Bovine Viral Diarrhea Virus in Heifers Vaccinated with a Combination of Multivalent Modified Live and Inactivated Viral Vaccines

Journal Article · Wed Mar 08 00:00:00 UTC 2023 · Viruses

DOI:https://doi.org/10.3390/v15030703· OSTI ID:2471250

^[1]; ^[2]; Crawford, Lauren ^[2]; Davila, Kaitlyn Sarlo ^[2]; Boggiatto, Paola ^[2]

US Dept. of Agriculture (USDA), Ames, IA (United States). Agricultural Research Service (ARS), National Animal Disease Center; Auburn University, AL (United States)
US Dept. of Agriculture (USDA), Ames, IA (United States). Agricultural Research Service (ARS), National Animal Disease Center

Bovine viral vaccines contain both live or inactivated/killed formulations, but few studies have evaluated the impact of vaccinating with either live or killed antigens and re-vaccinating with the reciprocal. Commercial dairy heifers were utilized for the study and randomly assigned to three treatment groups. Treatment groups received a commercially available modified-live viral (MLV) vaccine containing BVDV and were revaccinated with a commercially available killed viral (KV) vaccine containing BVDV, another group received the same KV vaccine and was revaccinated with the same MLV vaccine, and yet another group served as negative controls and did not receive any viral vaccines. Heifers in KV/MLV had higher virus neutralizing titers (VNT) at the end of the vaccination period than heifers in MLV/KV and control groups. The frequency of IFN-γ mRNA positive CD4+, CD8+, and CD335+ populations, as well as increased mean fluorescent intensity of CD25+ cells was increased for the MLV/KV heifers as compared to KV/MLV and controls. The data from this study would suggest that differences in initial antigen presentation such as live versus killed could augment CMI and humoral responses and could be useful in determining vaccination programs for optimizing protective responses, which is critical for promoting lifetime immunity.

View Accepted Manuscript (DOE)

Research Organization:: Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: SC0014664

OSTI ID:: 2471250

Journal Information:: Viruses, Journal Name: Viruses Journal Issue: 3 Vol. 15; ISSN 1999-4915

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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Response to Bovine Viral Diarrhea Virus in Heifers Vaccinated with a Combination of Multivalent Modified Live and Inactivated Viral Vaccines

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