The SEMA3F-NRP1/NRP2 axis is a key factor in the acquisition of invasive traits in in situ breast ductal carcinoma

Moragas, Núria; Fernandez-Nogueira, Patricia; Recalde-Percaz, Leire; Inman, Jamie L.; López-Plana, Anna; Bergholtz, Helga; Noguera-Castells, Aleix; del Burgo, Pedro J.; Chen, Xieng; Sorlie, Therese; Gascón, Pere; Bragado, Paloma; Bissell, Mina; Carbó, Neus; Fuster, Gemma

doi:10.1186/s13058-024-01871-0

The SEMA3F-NRP1/NRP2 axis is a key factor in the acquisition of invasive traits in in situ breast ductal carcinoma

Journal Article · Tue Aug 13 00:00:00 EDT 2024 · Breast Cancer Research

DOI:https://doi.org/10.1186/s13058-024-01871-0· OSTI ID:2470836

Moragas, Núria ^[1]; Fernandez-Nogueira, Patricia ^[1]; Recalde-Percaz, Leire ^[1]; Inman, Jamie L. ^[2]; López-Plana, Anna ^[1]; Bergholtz, Helga ^[3]; Noguera-Castells, Aleix ^[4]; del Burgo, Pedro J. ^[1]; Chen, Xieng ^[1]; Sorlie, Therese ^[3]; Gascón, Pere ^[1]; Bragado, Paloma ^[5]; Bissell, Mina ^[2]; Carbó, Neus ^[1]; Fuster, Gemma ^[6]

Universitat de Barcelona (Spain)
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Univ. of Oslo (Norway)
Universitat de Barcelona (Spain); Josep Carreras Leukaemia Research Institute (IJC), Barcelona (Spain); University of Vic - Central University of Catalonia (UVic-UCC), Barcelona (Spain)
Universidad Complutense de Madrid (Spain)
Universitat de Barcelona (Spain); Institute of Research and Innovation of Life Sciences and Health, Catalunya Central (IRIS-CC), Vic (Spain)

A better understanding of ductal carcinoma in situ (DCIS) is urgently needed to identify these preinvasive lesions as distinct clinical entities. Semaphorin 3F (SEMA3F) is a soluble axonal guidance molecule, and its coreceptors Neuropilin 1 (NRP1) and NRP2 are strongly expressed in invasive epithelial BC cells. We utilized two cell line models to represent the progression from a healthy state to the mild-aggressive or ductal carcinoma in situ (DCIS) stage and, ultimately, to invasive cell lines. Additionally, we employed in vivo models and conducted analyses on patient databases to ensure the translational relevance of our results. We revealed SEMA3F as a promoter of invasion during the DCIS-to-invasive ductal carcinoma transition in breast cancer (BC) through the action of NRP1 and NRP2. In epithelial cells, SEMA3F activates epithelialmesenchymal transition, whereas it promotes extracellular matrix degradation and basal membrane and myoepithelial cell layer breakdown. Together with our patient database data, these proof-of-concept results reveal new SEMA3F-mediated mechanisms occurring in the most common preinvasive BC lesion, DCIS, and represent potent and direct activation of its transition to invasion. Moreover, and of clinical and therapeutic relevance, the effects of SEMA3F can be blocked directly through its coreceptors, thus preventing invasion and keeping DCIS lesions in the preinvasive state.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 2470836

Journal Information:: Breast Cancer Research, Journal Name: Breast Cancer Research Journal Issue: 1 Vol. 26; ISSN 1465-542X

Publisher:: BioMed CentralCopyright Statement

Country of Publication:: United States

Language:: English

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Axonal guidance molecule
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Semaphorin 3F

The SEMA3F-NRP1/NRP2 axis is a key factor in the acquisition of invasive traits in in situ breast ductal carcinoma

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