The effect of ambient ozone exposure on three types of diabetes: a meta-analysis

Yu, Sirui; Zhang, Mingzhi; Zhu, Jiamin; Yang, Xu; Bigambo, Francis Manyori; Snijders, Antoine M.; Wang, Xu; Hu, Weiyue; Lv, Wei; Xia, Yankai

doi:10.1186/s12940-023-00981-0

The effect of ambient ozone exposure on three types of diabetes: a meta-analysis

Journal Article · Thu Mar 30 00:00:00 EDT 2023 · Environmental Health

DOI:https://doi.org/10.1186/s12940-023-00981-0· OSTI ID:2470794

Yu, Sirui ^[1]; Zhang, Mingzhi ^[1]; Zhu, Jiamin ^[1]; Yang, Xu ^[1]; Bigambo, Francis Manyori ^[1]; Snijders, Antoine M. ^[2]; Wang, Xu ^[3]; Hu, Weiyue ^[1]; Lv, Wei ^[4]; Xia, Yankai ^[1]

Nanjing Medical University (China)
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Children’s Hospital of Nanjing Medical University (China)
Nanjing University (China)

Background: Ozone as an air pollutant is gradually becoming a threat to people's health. However, the effect of ozone exposure on risk of developing diabetes, a fast-growing global metabolic disease, remains controversial. Objective: To evaluate the impact of ambient ozone exposure on the incidence rate of type 1, type 2 and gestational diabetes mellitus. Method: We systematically searched PubMed, Web of Science, and Cochrane Library databases before July 9, 2022, to determine relevant literature. Data were extracted after quality evaluation according to the Newcastle Ottawa Scale (NOS) and the agency for healthcare research and quality (AHRQ) standards, and a meta-analysis was used to evaluate the correlation between ozone exposure and type 1 diabetes mellitus (T1D), type 2 diabetes mellitus (T2D), and gestational diabetes mellitus (GDM). The heterogeneity test, sensitivity analysis, and publication bias were performed using Stata 16.0. Results: Our search identified 667 studies from three databases, 19 of which were included in our analysis after removing duplicate and ineligible studies. Among the remaining studies, three were on T1D, five were on T2D, and eleven were on GDM. The result showed that ozone exposure was positively correlated with T2D [effect size (ES) = 1.06, 95% CI: 1.02, 1.11] and GDM [pooled odds ratio (OR) = 1.01, 95% CI: 1.00, 1.03]. Subgroup analysis demonstrated that ozone exposure in the first trimester of pregnancy might raise the risk of GDM. However, no significant association was observed between ozone exposure and T1D. Conclusion: Long-term exposure to ozone may increase the risk of T2D, and daily ozone exposure during pregnancy was a hazard factor for developing GDM. Decreasing ambient ozone pollution may reduce the burden of both diseases.

View Accepted Manuscript (DOE)

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: China Program for Biomedical Collaborative Research NIEHS; China-U.S. Program for Biomedical Collaborative Research (NSFC-NIH); Jiangsu Province; National Natural Science Foundation of China; USDOE

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 2470794

Journal Information:: Environmental Health, Journal Name: Environmental Health Journal Issue: 1 Vol. 22; ISSN 1476-069X

Publisher:: BioMed CentralCopyright Statement

Country of Publication:: United States

Language:: English

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60 APPLIED LIFE SCIENCES
Air pollution
Environmental Sciences & Ecology
GDM
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Systematic review
T1D
T2D

The effect of ambient ozone exposure on three types of diabetes: a meta-analysis

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