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Differential patterns of reproductive and lifestyle risk factors for breast cancer according to birth cohorts among women in China, Japan and Korea

Journal Article · · Breast Cancer Research
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  1. Seoul National Univ. (Korea, Republic of)
  2. National Cancer Center Institute for Cancer Control, Tokyo (Japan)
  3. National Cancer Center Institute for Cancer Control, Tokyo (Japan); Hitotsubashi University, Tokyo (Japan)
  4. National Cancer Center Institute for Cancer Control, Tokyo (Japan); Hamamatsu University School of Medicine (Japan)
  5. Institute for Global Health Policy Research, Tokyo (Japan)
  6. Univ. of Sydney, NSW (Australia)
  7. National Cancer Center Institute for Cancer Control, Tokyo (Japan); National Institutes of Biomedical Innovation, Tokyo (Japan)
  8. Vanderbilt University Medical Center, Nashville, TN (United States)
  9. Hokkaido University, Sapporo (Japan)
  10. Radiation Effects Research Foundation (RERF), Hiroshima (Japan)
  11. Tohoku Univ., Sendai (Japan)
  12. National Cancer Center, Gyeonggi-do (Korea, Republic of)
  13. Gifu University Graduate School of Medicine (Japan)
  14. Chonnam National University Medical School, Gwangju (Korea, Republic of)
  15. Univ. of Chicago, IL (United States)
  16. Stony Brook Univ., NY (United States); Univ. of Bologna (Italy)
  17. National Univ. of Singapore (Singapore)
  18. Aichi Cancer Center Research Institute, Nagoya (Japan); Nagoya Univ. (Japan)
  19. Chinese Academy of Medical Sciences, Beijing (China); Peking Union Medical College, Beijing (China)
  20. National Cancer Institute, Bethesda, MD (United States)
+ Show Author Affiliations
Background: The birth cohort effect has been suggested to influence the rate of breast cancer incidence and the trends of associated reproductive and lifestyle factors. We conducted a cohort study to determine whether a differential pattern of associations exists between certain factors and breast cancer risk based on birth cohorts. Methods: This was a cohort study using pooled data from 12 cohort studies. We analysed associations between reproductive (menarche age, menopause age, parity and age at first delivery) and lifestyle (smoking and alcohol consumption) factors and breast cancer risk. We obtained hazard ratios (HRs) with 95% confidence intervals (CIs) using the Cox proportional hazard regression analysis on the 1920s, 1930s, 1940s and 1950s birth cohorts. Results: Parity was found to lower the risk of breast cancer in the older but not in the younger birth cohort, whereas lifestyle factors showed associations with breast cancer risk only among the participants born in the 1950s. In the younger birth cohort group, the effect size was lower for parous women compared to the other cohort groups (HR [95% CI] 0.86 [0.66–1.13] compared to 0.60 [0.49–0.73], 0.46 [0.38–0.56] and 0.62 [0.51–0.77]). Meanwhile, a higher effect size was found for smoking (1.45 [1.14–1.84] compared to 1.25 [0.99–1.58], 1.06 [0.85–1.32] and 0.86 [0.69–1.08]) and alcohol consumption (1.22 [1.01–1.48] compared to 1.10 [0.90–1.33], 1.15 [0.96–1.38], and 1.07 [0.91–1.26]). Conclusion: We observed different associations of parity, smoking and alcohol consumption with breast cancer risk across various birth cohorts.
Research Organization:
Radiation Effects Research Foundation (RERF), Hiroshima (Japan)
Sponsoring Organization:
National Research Foundation of Korea (NRF); USDOE
OSTI ID:
2470349
Journal Information:
Breast Cancer Research, Journal Name: Breast Cancer Research Journal Issue: 1 Vol. 26; ISSN 1465-542X
Publisher:
BioMed CentralCopyright Statement
Country of Publication:
United States
Language:
English

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Related Subjects

60 APPLIED LIFE SCIENCES
Asia
Background
Birth cohort
Breast cancer
Lifestyle factors
Reproductive factors
Women