Aptamer Applications in Neuroscience

Ozturk, Meric; Nilsen-Hamilton, Marit; Ilgu, Muslum

doi:10.3390/ph14121260

Aptamer Applications in Neuroscience

Journal Article · Fri Dec 03 00:00:00 EST 2021 · Pharmaceuticals

DOI:https://doi.org/10.3390/ph14121260· OSTI ID:2469934

Ozturk, Meric ^[1]; ^[2]; Ilgu, Muslum ^[3]

Iowa State University, Ames, IA (United States); Middle East Technical University, Ankara (Turkey)
Ames Laboratory, and Iowa State University, Ames, IA (United States)
Ames Laboratory, and Iowa State University, Ames, IA (United States); Middle East Technical University, Ankara (Turkey); Aptalogic Inc., Ames, IA (United States)

Being the predominant cause of disability, neurological diseases have received much attention from the global health community. Over a billion people suffer from one of the following neurological disorders: dementia, epilepsy, stroke, migraine, meningitis, Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, amyotrophic lateral sclerosis, Huntington’s disease, prion disease, or brain tumors. The diagnosis and treatment options are limited for many of these diseases. Aptamers, being small and non-immunogenic nucleic acid molecules that are easy to chemically modify, offer potential diagnostic and theragnostic applications to meet these needs. This review covers pioneering studies in applying aptamers, which shows promise for future diagnostics and treatments of neurological disorders that pose increasingly dire worldwide health challenges.

View Accepted Manuscript (DOE)

Research Organization:: Ames Laboratory (AMES), Ames, IA (United States)

Sponsoring Organization:: USDOE

Grant/Contract Number:: AC02-07CH11358

OSTI ID:: 2469934

Journal Information:: Pharmaceuticals, Journal Name: Pharmaceuticals Journal Issue: 12 Vol. 14; ISSN 1424-8247

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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Renal Dopamine Receptors and Hypertension Hussain, Tahir; Lokhandwala, Mustafa F. Experimental Biology and Medicine, Vol. 228, Issue 2 https://doi.org/10.1177/153537020322800202	journal	February 2003
The Spiegelmer NOX-A12, a novel CXCL12 inhibitor, interferes with chronic lymphocytic leukemia cell motility and causes chemosensitization Hoellenriegel, Julia; Zboralski, Dirk; Maasch, Christian Blood, Vol. 123, Issue 7 https://doi.org/10.1182/blood-2013-03-493924	journal	February 2014
Impaired dopamine metabolism in Parkinson’s disease pathogenesis Masato, Anna; Plotegher, Nicoletta; Boassa, Daniela Molecular Neurodegeneration, Vol. 14, Issue 1 https://doi.org/10.1186/s13024-019-0332-6	journal	August 2019
Possible strategies to cross the blood–brain barrier Bellettato, Cinzia M.; Scarpa, Maurizio Italian Journal of Pediatrics, Vol. 44, Issue S2 https://doi.org/10.1186/s13052-018-0563-0	journal	November 2018
Atlas of Multiple Sclerosis 2013: A growing global problem with widespread inequity Browne, P.; Chandraratna, D.; Angood, C. Neurology, Vol. 83, Issue 11 https://doi.org/10.1212/WNL.0000000000000768	journal	September 2014
RNA aptamers selectively modulate protein recruitment to the cytoplasmic domain of β-secretase BACE1 in vitro Rentmeister, Andrea; Bill, Anke; Wahle, Tina RNA, Vol. 12, Issue 9 https://doi.org/10.1261/rna.126306	journal	August 2006
RNA Aptamers Generated against Oligomeric Aβ40 Recognize Common Amyloid Aptatopes with Low Specificity but High Sensitivity Rahimi, Farid; Murakami, Kazuma; Summers, Jamie L. PLoS ONE, Vol. 4, Issue 11 https://doi.org/10.1371/journal.pone.0007694	journal	November 2009
Remyelination Induced by a DNA Aptamer in a Mouse Model of Multiple Sclerosis Nastasijevic, Branislav; Wright, Brent R.; Smestad, John PLoS ONE, Vol. 7, Issue 6 https://doi.org/10.1371/journal.pone.0039595	journal	June 2012
RAPID-SELEX for RNA Aptamers Szeto, Kylan; Latulippe, David R.; Ozer, Abdullah PLoS ONE, Vol. 8, Issue 12 https://doi.org/10.1371/journal.pone.0082667	journal	December 2013
Cell-SELEX Aptamer for Highly Specific Radionuclide Molecular Imaging of Glioblastoma In Vivo Wu, Xidong; Liang, Huiyu; Tan, Yan PLoS ONE, Vol. 9, Issue 3 https://doi.org/10.1371/journal.pone.0090752	journal	March 2014
A Synthetic Aptamer-Drug Adduct for Targeted Liver Cancer Therapy Trinh, Thu Le; Zhu, Guizhi; Xiao, Xilin PLOS ONE, Vol. 10, Issue 11 https://doi.org/10.1371/journal.pone.0136673	journal	November 2015
Aptamers as biomarkers for neurological disorders. Proof of concept in transgenic mice Lecocq, Soizic; Spinella, Katia; Dubois, Bruno PLOS ONE, Vol. 13, Issue 1 https://doi.org/10.1371/journal.pone.0190212	journal	January 2018
PET imaging of HER2 expression with an 18F-fluoride labeled aptamer Kim, Hyun Jeong; Park, Jun Young; Lee, Tae Sup PLOS ONE, Vol. 14, Issue 1 https://doi.org/10.1371/journal.pone.0211047	journal	January 2019
Treatment of Pituitary Tumors: Dopamine Agonists Iván, Gabriella; Szigeti-Csúcs, Nikoletta; Oláh, Márk Endocrine, Vol. 28, Issue 1 https://doi.org/10.1385/ENDO:28:1:101	journal	January 2005
The Application of Aptamers in Cancer Research: An Up-to-Date Review Hu, Meidi; Zhang, Kunhe Future Oncology, Vol. 9, Issue 3 https://doi.org/10.2217/fon.12.201	journal	March 2013
PET Imaging of Tenascin-C with a Radiolabeled Single-Stranded DNA Aptamer Jacobson, Orit; Yan, Xuefeng; Niu, Gang Journal of Nuclear Medicine, Vol. 56, Issue 4 https://doi.org/10.2967/jnumed.114.149484	journal	February 2015
¹⁸F-Labeled Single-Stranded DNA Aptamer for PET Imaging of Protein Tyrosine Kinase-7 Expression Jacobson, Orit; Weiss, Ido D.; Wang, Lu Journal of Nuclear Medicine, Vol. 56, Issue 11 https://doi.org/10.2967/jnumed.115.160960	journal	August 2015
Aptamer Cell-Based Selection: Overview and Advances Catuogno, Silvia; Esposito, Carla Lucia Biomedicines, Vol. 5, Issue 3 https://doi.org/10.3390/biomedicines5030049	journal	August 2017
Artificially Expanded Genetic Information Systems for New Aptamer Technologies Biondi, Elisa; Benner, Steven Biomedicines, Vol. 6, Issue 2 https://doi.org/10.3390/biomedicines6020053	journal	May 2018
Monoclonal Antibodies in Multiple Sclerosis: Present and Future Voge, Natalia V.; Alvarez, Enrique Biomedicines, Vol. 7, Issue 1 https://doi.org/10.3390/biomedicines7010020	journal	March 2019
Aptamer Sensors Marrazza, Giovanna Biosensors, Vol. 7, Issue 1 https://doi.org/10.3390/bios7010005	journal	January 2017
Aptamer Therapeutics in Cancer: Current and Future Morita, Yoshihiro; Leslie, Macall; Kameyama, Hiroyasu Cancers, Vol. 10, Issue 3 https://doi.org/10.3390/cancers10030080	journal	March 2018
Recent Advances in the Detection of Neurotransmitters Si, Bo; Song, Edward Chemosensors, Vol. 6, Issue 1 https://doi.org/10.3390/chemosensors6010001	journal	January 2018
Unraveling Prion Protein Interactions with Aptamers and Other PrP-Binding Nucleic Acids Macedo, Bruno; Cordeiro, Yraima International Journal of Molecular Sciences, Vol. 18, Issue 5 https://doi.org/10.3390/ijms18051023	journal	May 2017
Nucleic Acid Aptamers: Emerging Applications in Medical Imaging, Nanotechnology, Neurosciences, and Drug Delivery Röthlisberger, Pascal; Gasse, Cécile; Hollenstein, Marcel International Journal of Molecular Sciences, Vol. 18, Issue 11 https://doi.org/10.3390/ijms18112430	journal	November 2017
The Role of Protein Misfolding and Tau Oligomers (TauOs) in Alzheimer′s Disease (AD) Mroczko, Barbara; Groblewska, Magdalena; Litman-Zawadzka, Ala International Journal of Molecular Sciences, Vol. 20, Issue 19 https://doi.org/10.3390/ijms20194661	journal	September 2019
Methods and Applications of In Silico Aptamer Design and Modeling Buglak, Andrey A.; Samokhvalov, Alexey V.; Zherdev, Anatoly V. International Journal of Molecular Sciences, Vol. 21, Issue 22 https://doi.org/10.3390/ijms21228420	journal	November 2020
Aptamers for Anti-Viral Therapeutics and Diagnostics Kim, Tae-Hyeong; Lee, Seong-Wook International Journal of Molecular Sciences, Vol. 22, Issue 8 https://doi.org/10.3390/ijms22084168	journal	April 2021
Recent Advances in Aptamer Discovery and Applications Zhang, Yang; Lai, Bo Shiun; Juhas, Mario Molecules, Vol. 24, Issue 5 https://doi.org/10.3390/molecules24050941	journal	March 2019
Aptamer-Mediated Targeted Delivery of Therapeutics: An Update Catuogno, Silvia; Esposito, Carla; de Franciscis, Vittorio Pharmaceuticals, Vol. 9, Issue 4 https://doi.org/10.3390/ph9040069	journal	November 2016
Fast and Selective Plasmonic Serotonin Detection with Aptamer-Gold Nanoparticle Conjugates Chávez, Jorge; Hagen, Joshua; Kelley-Loughnane, Nancy Sensors, Vol. 17, Issue 4 https://doi.org/10.3390/s17040681	journal	March 2017
Huntington's disease: Molecular basis of pathology and status of current therapeutic approaches Huang, Wen-Juan; Chen, Wei-Wei; Zhang, Xia Experimental and Therapeutic Medicine, Vol. 12, Issue 4 https://doi.org/10.3892/etm.2016.3566	journal	August 2016
MRI contrast agents: Classification and application (Review) Xiao, Yu-Dong; Paudel, Ramchandra; Liu, Jun International Journal of Molecular Medicine, Vol. 38, Issue 5 https://doi.org/10.3892/ijmm.2016.2744	journal	September 2016
The novel amyloid-beta peptide aptamer inhibits intracellular amyloid-beta peptide toxicity Yang, Yu; Wu, Jiang; Wang, Xu Neural Regeneration Research, Vol. 8, Issue 1 https://doi.org/10.4103/1673-5374.126979	journal	January 2013
Aptamers in the Therapeutics and Diagnostics Pipelines Kaur, Harleen; Bruno, John G.; Kumar, Amit Theranostics, Vol. 8, Issue 15 https://doi.org/10.7150/thno.25958	journal	January 2018

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60 APPLIED LIFE SCIENCES
aptamer
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Aptamer Applications in Neuroscience

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