Improved titanium-44 purification process for establishing a high apparent molar activity titanium-44/scandium-44 generator

Huclier-Markai, Sandrine; Medvedev, D. G.; Cutler, C. S.

doi:10.1016/j.apradiso.2024.111451

Improved titanium-44 purification process for establishing a high apparent molar activity titanium-44/scandium-44 generator

Journal Article · Sat Jul 20 00:00:00 EDT 2024 · Applied Radiation and Isotopes

DOI:https://doi.org/10.1016/j.apradiso.2024.111451· OSTI ID:2438009

Huclier-Markai, Sandrine ^[1]; Medvedev, D. G. ^[2]; Cutler, C. S. ^[2]

Subatech (UMR 6457), Nantes (France); Nantes Université (France); IMT Atlantique, Nantes (France); Centre National de la Recherche Scientifique (CNRS), Nantes (France). Inst. National de Physique Nucleaire et de Physique des Particules (IN2P3); Aronnax, Saint Herblain (France); Brookhaven National Laboratory (BNL), Upton, NY (United States)
Brookhaven National Laboratory (BNL), Upton, NY (United States)

⁴⁴Sc-radiopharmaceuticals are gaining more interest but still lack availability. The proof of principle of a⁴⁴Ti/⁴⁴Sc generator, which can produce ⁴⁴Sc daily, has been established but with some limitations and drawbacks. Despite recent advances, separation of ⁴⁴Ti from massive quantities of scandium target material is still cumbersome. Here, in this work, the improved radiochemical separation of ⁴⁴Ti from residual scandium target material was carried out by precipitation of Sc with fluoride ions. Furthermore, two approaches were used to set up a high apparent molar activity small-scale generator. The first method relied on extraction chromatography for fine purification using a DGA resin, followed by loading of the purified ⁴⁴Ti onto a ZR resin column. In the second method, ⁴⁴Ti was loaded on the ZR resin directly after the precipitation step. This second method was used to set up a generator of 370 kBq and evaluate by radiolabeling. An apparent molar activity of 2 MBq/nmol was obtained for the radiolabeling with DOTA, the most common and suitable chelate for scandium. This result is comparable with previously published data on ^44m/44Sc.

View Accepted Manuscript (DOE)

Research Organization:: Brookhaven National Laboratory (BNL), Upton, NY (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Engineering & Technology. Office of Isotope R&D and Production

Grant/Contract Number:: SC0012704

OSTI ID:: 2438009

Alternate ID(s):: OSTI ID: 2407194

Report Number(s):: BNL--225979-2024-JAAM

Journal Information:: Applied Radiation and Isotopes, Journal Name: Applied Radiation and Isotopes Vol. 212; ISSN 0969-8043

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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