Mechanisms of Action of Dorsal Root Ganglion Stimulation

Abd-Elsayed, Alaa; Vardhan, Swarnima; Aggarwal, Abhinav; Vardhan, Madhurima; Diwan, Sudhir A.

doi:10.3390/ijms25073591

Mechanisms of Action of Dorsal Root Ganglion Stimulation

Journal Article · Fri Mar 22 00:00:00 EDT 2024 · International Journal of Molecular Sciences (Online)

DOI:https://doi.org/10.3390/ijms25073591· OSTI ID:2429408

Abd-Elsayed, Alaa ^[1]; Vardhan, Swarnima ^[2]; ^[3]; Vardhan, Madhurima ^[4]; Diwan, Sudhir A. ^[5]

Univ. of Wisconsin, Madison, WI (United States)
Yale New Haven Health, Bridgeport, CT (United States); Advanced Spine, New York, NY (United States)
Yale New Haven Health, Bridgeport, CT (United States)
Argonne National Laboratory (ANL), Argonne, IL (United States)
Advanced Spine, New York, NY (United States)

The dorsal root ganglion (DRG) serves as a pivotal site for managing chronic pain through dorsal root ganglion stimulation (DRG-S). In recent years, the DRG-S has emerged as an attractive modality in the armamentarium of neuromodulation therapy due to its accessibility and efficacy in alleviating chronic pain refractory to conventional treatments. Despite its therapeutic advantages, the precise mechanisms underlying DRG-S-induced analgesia remain elusive, attributed in part to the diverse sensory neuron population within the DRG and its modulation of both peripheral and central sensory processing pathways. Emerging evidence suggests that DRG-S may alleviate pain by several mechanisms, including the reduction of nociceptive signals at the T-junction of sensory neurons, modulation of pain gating pathways within the dorsal horn, and regulation of neuronal excitability within the DRG itself. However, elucidating the full extent of DRG-S mechanisms necessitates further exploration, particularly regarding its supraspinal effects and its interactions with cognitive and affective networks. Understanding these mechanisms is crucial for optimizing neurostimulation technologies and improving clinical outcomes of DRG-S for chronic pain management. This review provides a comprehensive overview of the DRG anatomy, mechanisms of action of the DRG-S, and its significance in neuromodulation therapy for chronic pain.

View Accepted Manuscript (DOE)

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 2429408

Journal Information:: International Journal of Molecular Sciences (Online), Journal Name: International Journal of Molecular Sciences (Online) Journal Issue: 7 Vol. 25; ISSN 1422-0067

Publisher:: MDPICopyright Statement

Country of Publication:: United States

Language:: English

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chronic pain
dorsal root ganglion stimulation
neuromodulation
neuropathic pain

Mechanisms of Action of Dorsal Root Ganglion Stimulation

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