Tailored Micromagnet Sorting Gate for Simultaneous Multiple Cell Screening in Portable Magnetophoretic Cell‐On‐Chip Platforms

Yoon, Jonghwan; Kang, Yumin; Kim, Hyeonseol; Ali, Abbas; Kim, Keonmok; Torati, Sri Ramulu; Im, Mi‐Young; Jeon, Changyeop; Lim, Byeonghwa; Kim, CheolGi

doi:10.1002/adfm.202312875

Tailored Micromagnet Sorting Gate for Simultaneous Multiple Cell Screening in Portable Magnetophoretic Cell‐On‐Chip Platforms

Journal Article · Mon Mar 04 23:00:00 EST 2024 · Advanced Functional Materials

DOI:https://doi.org/10.1002/adfm.202312875· OSTI ID:2318748

^[1]; ^[1]; ^[1]; Ali, Abbas ^[1]; Kim, Keonmok ^[1]; ^[1]; Im, Mi‐Young ^[2]; Jeon, Changyeop ^[1]; ^[3]; ^[1]

Department of Physics and Chemistry DGIST Daegu 42988 Republic of Korea
Center for X‐ray Optics Lawrence Berkeley National Laboratory Berkeley CA 94720 USA
Department of Smart Sensor Engineering Andong National University Andong 36729 Republic of Korea

Abstract

Conventional magnetophoresis techniques for manipulating biocarriers and cells predominantly rely on large‐scale electromagnetic systems, which is a major obstacle to the development of portable and miniaturized cell‐on‐chip platforms. Herein, a novel magnetic engineering approach by tailoring a nanoscale notch on a disk micromagnet using two‐step optical and thermal lithography is developed. Versatile manipulations are demonstrated, such as separation and trapping, of carriers and cells by mediating changes in the magnetic domain structure and discontinuous movement of magnetic energy wells around the circumferential edge of the micromagnet caused by a locally fabricated nano‐notch in a low magnetic field system. The motion of the magnetic energy well is regulated by the configuration of the nanoscale notch and the strength and frequency of the magnetic field, accompanying the jump motion of the carriers. The proposed concepts demonstrate that multiple carriers and cells can be manipulated and sorted using optimized nanoscale multi‐notch gates for a portable magnetophoretic system. This highlights the potential for developing cost‐effective point‐of‐care testing and lab‐on‐chip systems for various single‐cell‐level diagnoses and analyses.

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Sponsoring Organization:: USDOE

OSTI ID:: 2318748

Alternate ID(s):: OSTI ID: 2426595

Journal Information:: Advanced Functional Materials, Journal Name: Advanced Functional Materials Journal Issue: 27 Vol. 34; ISSN 1616-301X

Publisher:: Wiley Blackwell (John Wiley & Sons)Copyright Statement

Country of Publication:: Germany

Language:: English

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