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Divergent effects of sex and calcium/vitamin D supplementation on serum magnesium and markers of bone structure and function during initial military training

Journal Article · · British Journal of Nutrition
 [1];  [2];  [3];  [2];  [4];  [5]
  1. Florida State University, Tallahassee, FL (United States); US Army Research Institute of Environmental Medicine (USARIEM), Natick, MA (United States); Oak Ridge Institute for Science and Education, Belcamp, MD (United States)
  2. US Army Research Institute of Environmental Medicine (USARIEM), Natick, MA (United States); Oak Ridge Institute for Science and Education, Belcamp, MD (United States)
  3. Oak Ridge Institute for Science and Education, Belcamp, MD (United States); USARIEM, Natick, MA (United States)
  4. US Army Research Institute of Environmental Medicine (USARIEM), Natick, MA (United States)
  5. USARIEM, Natick, MA (United States)
+ Show Author Affiliations
Maintaining Mg status may be important for military recruits, a population that experiences high rates of stress fracture during initial military training (IMT). The objectives of this secondary analysis were to (1) compare dietary Mg intake and serum Mg in female and male recruits pre- and post-IMT, (2) determine whether serum Mg was related to parameters of bone health pre-IMT, and (3) whether Ca and vitamin D supplementation (Ca/vitamin D) during IMT modified serum Mg. Females (n 62) and males (n 51) consumed 2000 mg of Ca and 25 μg of vitamin D/d or placebo during IMT (12 weeks). Dietary Mg intakes were estimated using FFQ, serum Mg was assessed and peripheral quantitative computed tomography was performed on the tibia. Dietary Mg intakes for females and males pre-IMT were below the estimated average requirement and did not change with training. Serum Mg increased during IMT in females (0·06 ± 0·08 mmol/l) compared with males (–0·02 ± 0·10 mmol/l; P < 0·001) and in those consuming Ca/vitamin D (0·05 ± 0·09 mmol/l) compared with placebo (0·001 ± 0·11 mmol/l; P = 0·015). In females, serum Mg was associated with total bone mineral content (BMC, β = 0·367, P = 0·004) and robustness (β = 0·393, P = 0·006) at the distal 4 % site, stress–strain index of the polaris axis (β = 0·334, P = 0·009) and robustness (β = 0·420, P = 0·004) at the 14 % diaphyseal site, and BMC (β = 0·309, P = 0·009) and stress–strain index of the polaris axis (β = 0·314, P = 0·006) at the 66 % diaphyseal site pre-IMT. No significant relationships between serum Mg and bone measures were observed in males. Findings suggest that serum Mg may be modulated by Ca/vitamin D intake and may impact tibial bone health during training in female military recruits.
Research Organization:
Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)
Sponsoring Organization:
USDOE Office of Science (SC)
Grant/Contract Number:
SC0014664
OSTI ID:
2425645
Journal Information:
British Journal of Nutrition, Journal Name: British Journal of Nutrition Journal Issue: 9 Vol. 128; ISSN 0007-1145
Publisher:
Cambridge University PressCopyright Statement
Country of Publication:
United States
Language:
English

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Related Subjects

59 BASIC BIOLOGICAL SCIENCES
Dietary reference intakes
Magnesium status
Nutrition &amp; Dietetics
Reference interval
Serum magnesium