Characterizing how size distribution and concentration affect echogenicity of ultrasound contrast agents

Koo, Bonhye; Liu, Yunbo; Abboud, Monica; Qin, Bin; Wu, Yong; Choi, Stephanie; Kozak, Darby; Zheng, Jiwen

doi:10.1016/j.ultras.2022.106827

Characterizing how size distribution and concentration affect echogenicity of ultrasound contrast agents

Journal Article · Sat Aug 27 00:00:00 EDT 2022 · Ultrasonics

DOI:https://doi.org/10.1016/j.ultras.2022.106827· OSTI ID:2425607

Koo, Bonhye ^[1]; Liu, Yunbo ^[1]; Abboud, Monica ^[1]; Qin, Bin ^[1]; Wu, Yong ^[1]; Choi, Stephanie ^[1]; Kozak, Darby ^[1]; ^[1]

US Food and Drug Administration (USFDA), Silver Spring, MD (United States)

Here, we investigated the effects of UCA gas bubble size distribution and concentration on the generated ultrasound echogenicity signal. Gas bubble size characterization using Coulter Counter and cryogenic-SEM revealed the hollow structure and rare presence of microbubbles >10 µm in a commercial UCA product, Lumason™. Volume-weighed size and concentration were observed to be more sensitive to changes in UCA bubble stability than number-weighted size and concentration. Size distribution measurements showed that the force (e.g., shaking/agitation energy) used to redisperse the sample did not affect the size distribution, concentration, or echogenicity of the UCA sample. The ultrasound backscattering coefficient (BSC) of size fractionated and serial diluted microbubbles showed that the echogenicity signal correlates most with UCA bubble concentration, especially volume-weighted concentration. Findings from this study may be used to support demonstrating the equivalence of a generic UCA product to the reference listed drug.

View Accepted Manuscript (DOE)

Research Organization:: Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Science (SC)

Grant/Contract Number:: SC0014664

OSTI ID:: 2425607

Journal Information:: Ultrasonics, Journal Name: Ultrasonics Journal Issue: C Vol. 127; ISSN 0041-624X

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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73 NUCLEAR PHYSICS AND RADIATION PHYSICS
Acoustics
Backscattering coefficient
Coulter counter
Echogenicity
Radiology
Nuclear Medicine & Medical Imaging
Size distribution
Ultrasound contrast agent

Characterizing how size distribution and concentration affect echogenicity of ultrasound contrast agents

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References (35)

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