Advances in engineering algae for biofuel production

Ruffing, Anne M.; Davis, Ryan W.; Lane, Todd W.

doi:10.1016/j.copbio.2022.102830

Advances in engineering algae for biofuel production

Journal Article · Sat Oct 29 00:00:00 EDT 2022 · Current Opinion in Biotechnology

DOI:https://doi.org/10.1016/j.copbio.2022.102830· OSTI ID:2424756

Ruffing, Anne M. ^[1]; Davis, Ryan W. ^[2]; Lane, Todd W. ^[2]

Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)
Sandia National Laboratories (SNL-CA), Livermore, CA (United States)

While algae demonstrate potential as a sustainable fuel source, low productivities limit the economic realization of algal biofuels. High-throughput strain engineering, omics-informed genome-scale modeling, and microbiome engineering are key technologies for enabling algal biofuels. High-throughput strain engineering efforts generate improved traits, including high biomass productivity and lipid content, in diverse algal species. Genome-scale models, constructed with the aid of omics data, provide insight into metabolic limitations and guide rational algal strain engineering efforts. As outdoor cultivation systems introduce exogenous organisms, microbiome engineering seeks to eliminate harmful organisms and introduce beneficial species. In conclusion, optimizing algal biomass production and lipid content using these technologies may overcome the productivity barrier for the commercialization of algal biofuels.

View Accepted Manuscript (DOE)

Research Organization:: Sandia National Laboratories (SNL-CA), Livermore, CA (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: NA0003525

OSTI ID:: 2424756

Journal Information:: Current Opinion in Biotechnology, Journal Name: Current Opinion in Biotechnology Journal Issue: C Vol. 78; ISSN 0958-1669

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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