Recent Drug Development and Medicinal Chemistry Approaches for the Treatment of SARS‐CoV‐2 Infection and COVID‐19

Ghosh, Arun K.; Mishevich, Jennifer L.; Mesecar, Andrew; Mitsuya, Hiroaki

doi:10.1002/cmdc.202200440

Recent Drug Development and Medicinal Chemistry Approaches for the Treatment of SARS‐CoV‐2 Infection and COVID‐19

Journal Article · Thu Oct 13 04:00:00 EDT 2022 · ChemMedChem

DOI:https://doi.org/10.1002/cmdc.202200440· OSTI ID:2423579

^[1]; Mishevich, Jennifer L. ^[1]; Mesecar, Andrew ^[2]; Mitsuya, Hiroaki ^[3]

Department of Chemistry Purdue University West Lafayette IN 47907 USA; Department of Medicinal Chemistry and Molecular Pharmacology Purdue University West Lafayette IN 47907 USA
Department of Chemistry Purdue University West Lafayette IN 47907 USA; Department of Biological Sciences Purdue University West Lafayette IN 47907 USA; Department of Biochemistry Purdue University West Lafayette IN 47907 USA
Departments of Hematology and Infectious Diseases Kumamoto University School of Medicine Kumamoto 860-8556 Japan; Experimental Retrovirology Section HIV and AIDS Malignancy Branch National Cancer Institute Bethesda MD 20892 USA; National Center for Global Health and Medicine Research Institute Shinjuku Tokyo 162-8655 Japan

Abstract

COVID‐19, caused by SARS‐CoV‐2 infection, continues to be a major public health crisis around the globe. Development of vaccines and the first cluster of antiviral drugs has brought promise and hope for prevention and treatment of severe coronavirus disease. However, continued development of newer, safer, and more effective antiviral drugs are critically important to combat COVID‐19 and counter the looming pathogenic variants. Studies of the coronavirus life cycle revealed several important biochemical targets for drug development. In the present review, we focus on recent drug design and medicinal chemistry efforts in small molecule drug discovery, including the development of nirmatrelvir that targets viral protein synthesis and remdesivir and molnupiravir that target viral RdRp. These are recent FDA approved drugs for the treatment of COVID‐19.

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-06CH11357

OSTI ID:: 2423579

Journal Information:: ChemMedChem, Journal Name: ChemMedChem Journal Issue: 22 Vol. 17; ISSN 1860-7179

Publisher:: ChemPubSoc Europe

Country of Publication:: United States

Language:: English

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