Human Monoclonal IgE Antibodies—a Major Milestone in Allergy

Smith, Scott A.; Chruszcz, Maksymilian; Chapman, Martin D.; Pomés, Anna

doi:10.1007/s11882-022-01055-w

Human Monoclonal IgE Antibodies—a Major Milestone in Allergy

Journal Article · Fri Dec 02 00:00:00 EST 2022 · Current Allergy and Asthma Reports

DOI:https://doi.org/10.1007/s11882-022-01055-w· OSTI ID:2423460

^[1]; Chruszcz, Maksymilian ^[2]; ^[3]; ^[3]

Vanderbilt Univ., Nashville, TN (United States)
Univ. of South Carolina, Columbia, SC (United States)
InBio, Charlottesville, VA (United States)

This review provides an overview of this major milestone in allergy, the first atomic resolution structure of an authentic human IgE epitope. The molecular insights that IgE epitopes provide will allow for structure-based design approaches to the development of novel diagnostics, antibody therapeutics, and immunotherapies.

View Accepted Manuscript (DOE)

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 2423460

Journal Information:: Current Allergy and Asthma Reports, Journal Name: Current Allergy and Asthma Reports Journal Issue: 1 Vol. 23; ISSN 1529-7322

Publisher:: SpringerCopyright Statement

Country of Publication:: United States

Language:: English

References (85)

Epstein‐Barr virus‐induced IgE production in limiting dilution cultures of normal human B cells Stein, Leonard D.; Chan, Marcia A.; Hibi, Toshifumi European Journal of Immunology, Vol. 16, Issue 9 https://doi.org/10.1002/eji.1830160922	journal	January 1986
Inefficient processing of mRNA for the membraneform of IgE is a genetic mechanism to limit recruitment of IgE‐secreting cells Karnowski, Alexander; Achatz‐Straussberger, Gertrude; Klockenbusch, Cordula European Journal of Immunology, Vol. 36, Issue 7 https://doi.org/10.1002/eji.200535495	journal	June 2006
IgE antibody-specific activity in human allergic disease Hamilton, Robert G.; MacGlashan, Donald W.; Saini, Sarbjit S. Immunologic Research, Vol. 47, Issue 1-3 https://doi.org/10.1007/s12026-009-8160-3	journal	January 2010
The Epstein-Barr virus-induced production of IgE by human B cells Martinez-Maza, Otoniel; Guilbert, Brigitte; David, Bernard Clinical Immunology and Immunopathology, Vol. 39, Issue 3 https://doi.org/10.1016/0090-1229(86)90168-6	journal	June 1986
IgE binding structures of the major house dust mite allergen DER P I Greene, W. K.; Thomas, W. R. Molecular Immunology, Vol. 29, Issue 2 https://doi.org/10.1016/0161-5890(92)90107-9	journal	February 1992
Molecular characterization of human IgG monoclonal antibodies specific for the major birch pollen allergen Bet v 1. Anti‐allergen IgG can enhance the anaphylactic reaction Denépoux, Stéphane; Eibensteiner, Petra B.; Steinberger, Peter FEBS Letters, Vol. 465, Issue 1 https://doi.org/10.1016/S0014-5793(99)01703-2	journal	December 1999
The Crystal Structure of a Major Dust Mite Allergen Der p 2, and its Biological Implications Derewenda, U.; Li, J.; Derewenda, Z. Journal of Molecular Biology, Vol. 318, Issue 1 https://doi.org/10.1016/S0022-2836(02)00027-X	journal	April 2002
Production of a mouse/human chimeric IgE monoclonal antibody to the house dust mite allergen Der p 2 and its use for the absolute quantification of allergen-specific IgE Schuurman, J.; Perdok, G.; Lourens, T. Journal of Allergy and Clinical Immunology, Vol. 99, Issue 4 https://doi.org/10.1016/S0091-6749(97)70083-6	journal	April 1997
Epitope mapping of the major allergen 2S albumin from pine nut Crespo, Jesus F.; Bueno, Cristina; Villalba, Mayte Food Chemistry, Vol. 339 https://doi.org/10.1016/j.foodchem.2020.127895	journal	March 2021
The IgE repertoire in PBMCs of atopic patients is characterized by individual rearrangements without variable region of the heavy immunoglobulin chain bias Lim, Annick; Luderschmidt, Stephan; Weidinger, Anke Journal of Allergy and Clinical Immunology, Vol. 120, Issue 3 https://doi.org/10.1016/j.jaci.2007.05.035	journal	September 2007
Several distinct properties of the IgE repertoire determine effector cell degranulation in response to allergen challenge Christensen, Lars Harder; Holm, Jens; Lund, Gitte Journal of Allergy and Clinical Immunology, Vol. 122, Issue 2 https://doi.org/10.1016/j.jaci.2008.05.026	journal	August 2008
Alternaria alternata allergen Alt a 1: A unique β-barrel protein dimer found exclusively in fungi Chruszcz, Maksymilian; Chapman, Martin D.; Osinski, Tomasz Journal of Allergy and Clinical Immunology, Vol. 130, Issue 1 https://doi.org/10.1016/j.jaci.2012.03.047	journal	July 2012
Human IgE+ B cells are derived from T cell–dependent and T cell–independent pathways Berkowska, Magdalena A.; Heeringa, Jorn J.; Hajdarbegovic, Enes Journal of Allergy and Clinical Immunology, Vol. 134, Issue 3 https://doi.org/10.1016/j.jaci.2014.03.036	journal	September 2014
Single B-cell deconvolution of peanut-specific antibody responses in allergic patients Hoh, Ramona A.; Joshi, Shilpa A.; Liu, Yi Journal of Allergy and Clinical Immunology, Vol. 137, Issue 1 https://doi.org/10.1016/j.jaci.2015.05.029	journal	January 2016
Human B-cell isotype switching origins of IgE Looney, Timothy J.; Lee, Ji-Yeun; Roskin, Krishna M. Journal of Allergy and Clinical Immunology, Vol. 137, Issue 2 https://doi.org/10.1016/j.jaci.2015.07.014	journal	February 2016
IgE epitope proximity determines immune complex shape and effector cell activation capacity Gieras, Anna; Linhart, Birgit; Roux, Kenneth H. Journal of Allergy and Clinical Immunology, Vol. 137, Issue 5 https://doi.org/10.1016/j.jaci.2015.08.055	journal	May 2016
The number and affinity of productive IgE pairs determine allergen activation of mast cells Hjort, Charlotte; Schiøtz, Peter Oluf; Ohlin, Mats Journal of Allergy and Clinical Immunology, Vol. 140, Issue 4 https://doi.org/10.1016/j.jaci.2017.04.014	journal	October 2017
Identification of bee venom Api m 1 IgE epitopes and characterization of corresponding mimotopes Zahirović, Abida; Koren, Ana; Kopač, Peter Journal of Allergy and Clinical Immunology, Vol. 143, Issue 2 https://doi.org/10.1016/j.jaci.2018.10.003	journal	February 2019
Predicting development of sustained unresponsiveness to milk oral immunotherapy using epitope-specific antibody binding profiles Suárez-Fariñas, Mayte; Suprun, Maria; Chang, Helena L. Journal of Allergy and Clinical Immunology, Vol. 143, Issue 3 https://doi.org/10.1016/j.jaci.2018.10.028	journal	March 2019
Allergome-wide peptide microarrays enable epitope deconvolution in allergen-specific immunotherapy Mikus, Maria; Zandian, Arash; Sjöberg, Ronald Journal of Allergy and Clinical Immunology, Vol. 147, Issue 3 https://doi.org/10.1016/j.jaci.2020.08.002	journal	March 2021
Early epitope-specific IgE antibodies are predictive of childhood peanut allergy Suprun, Maria; Sicherer, Scott H.; Wood, Robert A. Journal of Allergy and Clinical Immunology, Vol. 146, Issue 5 https://doi.org/10.1016/j.jaci.2020.08.005	journal	November 2020
Ara h 2–specific IgE is superior to whole peanut extract–based serology or skin prick test for diagnosis of peanut allergy in infancy Keet, Corinne; Plesa, Mihaela; Szelag, Daria Journal of Allergy and Clinical Immunology, Vol. 147, Issue 3 https://doi.org/10.1016/j.jaci.2020.11.034	journal	March 2021
Evolution of epitope-specific IgE and IgG4 antibodies in children enrolled in the LEAP trial Suarez-Farinas, Mayte; Suprun, Maria; Bahnson, Henry T. Journal of Allergy and Clinical Immunology, Vol. 148, Issue 3 https://doi.org/10.1016/j.jaci.2021.01.030	journal	September 2021
Isotype-specific binding patterns of serum antibodies to multiple conformational epitopes of Bet v 1 Schmalz, Stefanie; Mayr, Vanessa; Shosherova, Alexandra Journal of Allergy and Clinical Immunology, Vol. 149, Issue 5 https://doi.org/10.1016/j.jaci.2021.10.026	journal	May 2022
Label-free epitope binning assays of monoclonal antibodies enable the identification of antigen heterogeneity Abdiche, Yasmina N.; Lindquist, Kevin C.; Stone, Donna M. Journal of Immunological Methods, Vol. 382, Issue 1-2 https://doi.org/10.1016/j.jim.2012.05.010	journal	August 2012
IgE and IgG4 epitopes revealed on the major fish allergen Lat c 1 Sharp, Michael F.; Taki, Aya C.; Ruethers, Thimo Molecular Immunology, Vol. 131 https://doi.org/10.1016/j.molimm.2020.12.033	journal	March 2021
Molecular Interactions between a Recombinant IgE Antibody and the β-Lactoglobulin Allergen Niemi, Merja; Jylhä, Sirpa; Laukkanen, Marja-Leena Structure, Vol. 15, Issue 11 https://doi.org/10.1016/j.str.2007.09.012	journal	November 2007
High-resolution epitope mapping by AllerScan reveals relationships between IgE and IgG repertoires during peanut oral immunotherapy Chen, Genghao; Shrock, Ellen L.; Li, Mamie Z. Cell Reports Medicine, Vol. 2, Issue 10 https://doi.org/10.1016/j.xcrm.2021.100410	journal	October 2021
Trivalent Ligands with Rigid DNA Spacers Reveal Structural Requirements For IgE Receptor Signaling in RBL Mast Cells Sil, Dwaipayan; Lee, Jong Bum; Luo, Dan ACS Chemical Biology, Vol. 2, Issue 10 https://doi.org/10.1021/cb7001472	journal	October 2007
Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen Smith, Kenneth; Garman, Lori; Wrammert, Jens Nature Protocols, Vol. 4, Issue 3 https://doi.org/10.1038/nprot.2009.3	journal	February 2009
The production and regulation of IgE by the immune system Wu, Lawren C.; Zarrin, Ali A. Nature Reviews Immunology, Vol. 14, Issue 4 https://doi.org/10.1038/nri3632	journal	March 2014
Clustering of conformational IgE epitopes on the major dog allergen Can f 1 Curin, Mirela; Weber, Milena; Hofer, Gerhard Scientific Reports, Vol. 7, Issue 1 https://doi.org/10.1038/s41598-017-11672-5	journal	September 2017
Conformational IgE Epitope Mapping of Der p 2 and the Evaluations of Two Candidate Hypoallergens for Immunotherapy Reginald, Kavita; Chew, Fook Tim Scientific Reports, Vol. 8, Issue 1 https://doi.org/10.1038/s41598-018-21792-1	journal	February 2018
Novel Bead-Based Epitope Assay is a sensitive and reliable tool for profiling epitope-specific antibody repertoire in food allergy Suprun, Maria; Getts, Robert; Raghunathan, Rohit Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-54868-7	journal	December 2019
A native IgE in complex with profilin provides insights into allergen recognition and cross-reactivity García-Ramírez, Benjamín; Mares-Mejía, Israel; Rodríguez-Hernández, Annia Communications Biology, Vol. 5, Issue 1 https://doi.org/10.1038/s42003-022-03718-w	journal	July 2022
Clinical Aspects of IgE Myeloma Ogawa, Makio; Kochwa, Shaul; Smith, Charles New England Journal of Medicine, Vol. 281, Issue 22 https://doi.org/10.1056/NEJM196911272812204	journal	November 1969
Use of phage display technology to investigate allergen-antibody interactions Davies, Janet M.; O’Hehir, Robyn E.; Suphioglu, Cenk Journal of Allergy and Clinical Immunology, Vol. 105, Issue 6 https://doi.org/10.1067/mai.2000.107040	journal	June 2000
Mapping epitopes and antigenicity by site-directed masking Paus, Didrik; Winter, Greg Proceedings of the National Academy of Sciences, Vol. 103, Issue 24 https://doi.org/10.1073/pnas.0600263103	journal	June 2006
Human-human hybridomas producing monoclonal antibodies of predefined antigenic specificity. Olsson, L.; Kaplan, H. S. Proceedings of the National Academy of Sciences, Vol. 77, Issue 9 https://doi.org/10.1073/pnas.77.9.5429	journal	September 1980
Construction of a Combinatorial IgE Library from an Allergic Patient Steinberger, Peter; Kraft, Dietrich; Valenta, Rudolf Journal of Biological Chemistry, Vol. 271, Issue 18 https://doi.org/10.1074/jbc.271.18.10967	journal	May 1996
Crystal Structure of a Dimerized Cockroach Allergen Bla g 2 Complexed with a Monoclonal Antibody Li, Mi; Gustchina, Alla; Alexandratos, Jerry Journal of Biological Chemistry, Vol. 283, Issue 33 https://doi.org/10.1074/jbc.M800937200	journal	June 2008
Molecular characterization of a fungal cyclophilin allergen Rhi o 2 and elucidation of antigenic determinants responsible for IgE–cross-reactivity Sircar, Gaurab; Bhowmik, Moumita; Sarkar, Rajat Kanti Journal of Biological Chemistry, Vol. 295, Issue 9 https://doi.org/10.1074/jbc.RA119.011659	journal	February 2020
Hydrogen/deuterium exchange memory NMR reveals structural epitopes involved in IgE cross-reactivity of allergenic lipid transfer proteins Di Muzio, Martina; Wildner, Sabrina; Huber, Sara Journal of Biological Chemistry, Vol. 295, Issue 51 https://doi.org/10.1074/jbc.RA120.014243	journal	December 2020
Human Monoclonal Antibodies Derived From Memory B Cells Following Live Attenuated Dengue Virus Vaccination or Natural Infection Exhibit Similar Characteristics Smith, Scott A.; de Alwis, Ruklanthi; Kose, Nurgun The Journal of Infectious Diseases, Vol. 207, Issue 12 https://doi.org/10.1093/infdis/jit119	journal	March 2013
Human IgE monoclonal antibody recognition of mite allergen Der p 2 defines structural basis of an epitope for IgE cross-linking and anaphylaxis in vivo Khatri, Kriti; Richardson, Crystal M.; Glesner, Jill PNAS Nexus, Vol. 1, Issue 3 https://doi.org/10.1093/pnasnexus/pgac054	journal	June 2022
IgE‐expressing memory B cells and plasmablasts are increased in blood of children with asthma, food allergy, and atopic dermatitis Heeringa, J. J.; Rijvers, L.; Arends, N. J. Allergy, Vol. 73, Issue 6 https://doi.org/10.1111/all.13421	journal	March 2018
Preventive sublingual immunotherapy with House Dust Mite extract modulates epitope diversity in pre‐school children Ponce, Marta; Schroeder, Fabian; Bannert, Christina Allergy, Vol. 74, Issue 4 https://doi.org/10.1111/all.13658	journal	January 2019
IgE to epitopes of Ara h 2 enhance the diagnostic accuracy of Ara h 2‐specific IgE Santos, Alexandra F.; Barbosa‐Morais, Nuno L.; Hurlburt, Barry K. Allergy, Vol. 75, Issue 9 https://doi.org/10.1111/all.14301	journal	April 2020
Basophil activation test: Mechanisms and considerations for use in clinical trials and clinical practice Santos, Alexandra F.; Alpan, Oral; Hoffmann, Hans‐Jürgen Allergy, Vol. 76, Issue 8 https://doi.org/10.1111/all.14747	journal	February 2021
Accurate and reproducible diagnosis of peanut allergy using epitope mapping Suárez‐Fariñas, Mayte; Suprun, Maria; Kearney, Paul Allergy, Vol. 76, Issue 12 https://doi.org/10.1111/all.14905	journal	June 2021
Can alternative epitope mapping approaches increase the impact of B‐cell epitopes in food allergy diagnostics? Ehlers, Anna M.; Blankestijn, Mark A.; Knulst, Andre C. Clinical & Experimental Allergy, Vol. 49, Issue 1 https://doi.org/10.1111/cea.13291	journal	October 2018
Ara h 7 isoforms share many linear epitopes: Are 3D epitopes crucial to elucidate divergent abilities? Ehlers, Anna M.; Klinge, Marco; Suer, Waltraud Clinical & Experimental Allergy, Vol. 49, Issue 11 https://doi.org/10.1111/cea.13496	journal	October 2019
Detection of specific IgE against linear epitopes from Gal d 1 has additional value in diagnosing hen’s egg allergy in adults Ehlers, Anna M.; Otten, Henny G.; Wierzba, Eva Clinical & Experimental Allergy, Vol. 50, Issue 12 https://doi.org/10.1111/cea.13730	journal	September 2020
The complexity of allergic patients' IgE repertoire correlates with serum concentration of allergen‐specific IgE Willumsen, N.; Holm, J.; Christensen, L. H. Clinical & Experimental Allergy, Vol. 42, Issue 8 https://doi.org/10.1111/j.1365-2222.2012.04009.x	journal	July 2012
CD23/FcεRII: molecular multi-tasking Acharya, M.; Borland, G.; Edkins, A. L. Clinical and Experimental Immunology, Vol. 162, Issue 1 https://doi.org/10.1111/j.1365-2249.2010.04210.x	journal	September 2010
Mapping and Mutational Analysis of the IgE-Binding Epitopes on Ara h 1, a Legume Vicilin Protein and a Major Allergen in Peanut Hypersensitivity Burks, A. Wesley; Shin, David; Cockrell, Gael European Journal of Biochemistry, Vol. 245, Issue 2 https://doi.org/10.1111/j.1432-1033.1997.t01-1-00334.x	journal	April 1997
IgE binding to linear epitopes of Ara h 2 in peanut allergic preschool children undergoing oral Immunotherapy Dreskin, Stephen C.; Germinaro, Matthew; Reinhold, Dominik Pediatric Allergy and Immunology, Vol. 30, Issue 8 https://doi.org/10.1111/pai.13117	journal	October 2019
IgE and IgG4 binding to lentil epitopes in children with red and green lentil allergy Sackesen, Cansin; Erman, Baran; Gimenez, Gustavo Pediatric Allergy and Immunology, Vol. 31, Issue 2 https://doi.org/10.1111/pai.13136	journal	November 2019
Molecular Editing of Cellular Responses by the High-Affinity Receptor for IgE Suzuki, R.; Leach, S.; Liu, W. Science, Vol. 343, Issue 6174 https://doi.org/10.1126/science.1246976	journal	February 2014
Effect of Transmembrane and Cytoplasmic Domains of IgE on the IgE Response Achatz, Gernot; Nitschke, Lars; Lamers, Marinus C. Science, Vol. 276, Issue 5311 https://doi.org/10.1126/science.276.5311.409	journal	April 1997
High-affinity allergen-specific human antibodies cloned from single IgE B cell transcriptomes Croote, Derek; Darmanis, Spyros; Nadeau, Kari C. Science, Vol. 362, Issue 6420 https://doi.org/10.1126/science.aau2599	journal	December 2018
Isolation of Dengue Virus-Specific Memory B Cells with Live Virus Antigen from Human Subjects following Natural Infection Reveals the Presence of Diverse Novel Functional Groups of Antibody Clones Smith, Scott A.; de Alwis, A. Ruklanthi; Kose, Nurgun Journal of Virology, Vol. 88, Issue 21 https://doi.org/10.1128/JVI.00247-14	journal	November 2014
Persistence of Circulating Memory B Cell Clones with Potential for Dengue Virus Disease Enhancement for Decades following Infection Smith, S. A.; Zhou, Y.; Olivarez, N. P. Journal of Virology, Vol. 86, Issue 5 https://doi.org/10.1128/JVI.06335-11	journal	December 2011
The Potent and Broadly Neutralizing Human Dengue Virus-Specific Monoclonal Antibody 1C19 Reveals a Unique Cross-Reactive Epitope on the bc Loop of Domain II of the Envelope Protein Smith, Scott A.; de Alwis, A. Ruklanthi; Kose, Nurgun mBio, Vol. 4, Issue 6 https://doi.org/10.1128/mBio.00873-13	journal	December 2013
The production and characterisation of a chimaeric human IgE antibody, recognising the major mite allergen Der p 1, and its chimaeric human IgG1 anti-idiotype Furtado, P. B. Molecular Pathology, Vol. 55, Issue 5 https://doi.org/10.1136/mp.55.5.315	journal	October 2002
The Human IgE Repertoire Gadermaier, Elisabeth; Levin, Mattias; Flicker, Sabine International Archives of Allergy and Immunology, Vol. 163, Issue 2 https://doi.org/10.1159/000355947	journal	November 2013
A Novel Multipeptide Microarray for the Specific and Sensitive Mapping of Linear IgE-Binding Epitopes of Food Allergens Kühne, Yvonne; Reese, Gerald; Ballmer-Weber, Barbara K. International Archives of Allergy and Immunology, Vol. 166, Issue 3 https://doi.org/10.1159/000381344	journal	January 2015
Human IgE mAbs define variability in commercial Aspergillus extract allergen composition Wurth, Mark A.; Hadadianpour, Azadeh; Horvath, Dennis J. JCI Insight, Vol. 3, Issue 20 https://doi.org/10.1172/jci.insight.123387	journal	October 2018
STAT3 is required for IL-21–induced secretion of IgE from human naive B cells Avery, Danielle T.; Ma, Cindy S.; Bryant, Vanessa L. Blood, Vol. 112, Issue 5 https://doi.org/10.1182/blood-2008-02-142745	journal	September 2008
Mitogen-Induced B-Cell Proliferation Activates Chk2-Dependent G1/S Cell Cycle Arrest Nikitin, Pavel A.; Price, Alexander M.; McFadden, Karyn PLoS ONE, Vol. 9, Issue 1 https://doi.org/10.1371/journal.pone.0087299	journal	January 2014
Engineering, Purification and Applications of His-Tagged Recombinant Antibody Fragments with Specificity for the Major Birch Pollen Allergen, Bet v1 Flicker, Sabine; Laffer, Sylvia; Steinberger, Peter Biological Chemistry, Vol. 381, Issue 1 https://doi.org/10.1515/BC.2000.006	journal	January 2000
Antibody Specific B-Cell Epitope Predictions: Leveraging Information From Antibody-Antigen Protein Complexes Jespersen, Martin Closter; Mahajan, Swapnil; Peters, Bjoern Frontiers in Immunology, Vol. 10 https://doi.org/10.3389/fimmu.2019.00298	journal	February 2019
Structural Aspects of the Allergen-Antibody Interaction Pomés, Anna; Mueller, Geoffrey A.; Chruszcz, Maksymilian Frontiers in Immunology, Vol. 11 https://doi.org/10.3389/fimmu.2020.02067	journal	September 2020
IgE Epitope Profiling for Allergy Diagnosis and Therapy – Parallel Analysis of a Multitude of Potential Linear Epitopes Using a High Throughput Screening Platform Krause, Thorsten; Röckendorf, Niels; Meckelein, Barbara Frontiers in Immunology, Vol. 11 https://doi.org/10.3389/fimmu.2020.565243	journal	September 2020
IgE Epitopes of the House Dust Mite Allergen Der p 7 Are Mainly Discontinuous and Conformational Curin, Mirela; Huang, Huey-Jy; Garmatiuk, Tetiana Frontiers in Immunology, Vol. 12 https://doi.org/10.3389/fimmu.2021.687294	journal	June 2021
Tuning IgE: IgE-Associating Molecules and Their Effects on IgE-Dependent Mast Cell Reactions Ando, Tomoaki; Kitaura, Jiro Cells, Vol. 10, Issue 7 https://doi.org/10.3390/cells10071697	journal	July 2021
High-Affinity IgE Recognition of a Conformational Epitope of the Major Respiratory Allergen Phl p 2 As Revealed by X-Ray Crystallography Padavattan, Sivaraman; Flicker, Sabine; Schirmer, Tilman The Journal of Immunology, Vol. 182, Issue 4 https://doi.org/10.4049/jimmunol.0803018	journal	February 2009
Carbohydrates Contribute to the Interactions between Cockroach Allergen Bla g 2 and a Monoclonal Antibody Li, Mi; Gustchina, Alla; Glesner, Jill The Journal of Immunology, Vol. 186, Issue 1 https://doi.org/10.4049/jimmunol.1002318	journal	December 2010
A human IgE myeloma protein named PS and Sha. Molinaro, G. A.; Eby, W. C. The Journal of Immunology, Vol. 136, Issue 3 https://doi.org/10.4049/jimmunol.136.3.1136	journal	February 1986
Differential inhibition of T and B cell function in IL-4-dependent IgE production by cyclosporin A and methylprednisolone. Renz, H.; Mazer, B. D.; Gelfand, E. W. The Journal of Immunology, Vol. 145, Issue 11 https://doi.org/10.4049/jimmunol.145.11.3641	journal	December 1990
A Human Monoclonal IgE Antibody Defines a Highly Allergenic Fragment of the Major Timothy Grass Pollen Allergen, Phl p 5: Molecular, Immunological, and Structural Characterization of the Epitope-Containing Domain Flicker, Sabine; Vrtala, Susanne; Steinberger, Peter The Journal of Immunology, Vol. 165, Issue 7 https://doi.org/10.4049/jimmunol.165.7.3849	journal	October 2000
Bivalent Ligands with Rigid Double-Stranded DNA Spacers Reveal Structural Constraints on Signaling by FcεRI Paar, Jodi M.; Harris, Nancie T.; Holowka, David The Journal of Immunology, Vol. 169, Issue 2 https://doi.org/10.4049/jimmunol.169.2.856	journal	July 2002
A Human IgE Antibody Binding Site on Der p 2 for the Design of a Recombinant Allergen for Immunotherapy Glesner, Jill; Kapingidza, A. Brenda; Godzwon, Magdalena The Journal of Immunology, Vol. 203, Issue 9 https://doi.org/10.4049/jimmunol.1900580	journal	September 2019
Mapping Human Monoclonal IgE Epitopes on the Major Dust Mite Allergen Der p 2 Mueller, Geoffrey A.; Glesner, Jill; Daniel, Jacob L. The Journal of Immunology, Vol. 205, Issue 8 https://doi.org/10.4049/jimmunol.2000295	journal	September 2020
Identification of γE-Antibodies as a Carrier of Reaginic Activity Ishizaka, Kimishige; Ishizaka, Teruko The Journal of Immunology, Vol. 99, Issue 6 https://doi.org/10.4049/jimmunol.99.6.1187	journal	December 1967

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59 BASIC BIOLOGICAL SCIENCES
allergens
allergy
conformational epitope
diagnosis
human IgE monoclonal antibody
x-ray crystallography

Human Monoclonal IgE Antibodies—a Major Milestone in Allergy

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