Describing the Influence of Ball-milling on the Amorphization of Flubendazole Using the PDF and RMC Methods with X-ray Powder Diffraction Data

Bezzon, Vinícius Danilo Nonato; Pinto, Rogério da Silva; de Araújo, Gabriel Barros; de Lima, João Cardoso; Ferreira, Fabio Furlan

doi:10.1016/j.xphs.2022.06.018

Describing the Influence of Ball-milling on the Amorphization of Flubendazole Using the PDF and RMC Methods with X-ray Powder Diffraction Data

Journal Article · Sun Jun 26 00:00:00 EDT 2022 · Journal of Pharmaceutical Sciences

DOI:https://doi.org/10.1016/j.xphs.2022.06.018· OSTI ID:2423371

^[1]; Pinto, Rogério da Silva ^[1]; ^[2]; de Lima, João Cardoso ^[3]; ^[1]

Federal University of ABC (UFABC), Santo André, SP (Brazil)
University of São Paulo, SP (Brazil)
Federal University of Santa Catarina, Florianópolis, SC (Brazil)

Flubendazole (FBZ) is a poorly water-soluble drug, and different methodologies have been proposed to improve its oral bioavailability. Obtaining the amorphous drug phase is an alternative to improve its water solubility. Several techniques for drug amorphization, such as spray drying, lyophilization, melt quenching, solvent-evaporation, and ball milling, can yield various types of structural disorder and possibly render variations in physicochemical properties. Herein, we focus on evaluating the influence of the ball-milling process on the amorphization of FBZ. The characterization of the average global and local structures before, during, and after the milling process is described by sequential Rietveld refinements, pair distribution function analysis, and the Reverse Monte Carlo method. In conclusion, we show that preserving the local structure (nearest molecules) can be responsible for avoiding the fast structure recrystallization commonly observed when using the solvent-evaporation process for the studied drug.

View Accepted Manuscript (DOE)

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)

Sponsoring Organization:: São Paulo Research Foundation (FAPESP); USDOE Office of Science (SC), Basic Energy Sciences (BES). Scientific User Facilities (SUF)

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 2423371

Journal Information:: Journal of Pharmaceutical Sciences, Journal Name: Journal of Pharmaceutical Sciences Journal Issue: 11 Vol. 111; ISSN 0022-3549

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Describing the Influence of Ball-milling on the Amorphization of Flubendazole Using the PDF and RMC Methods with X-ray Powder Diffraction Data

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