Comparative developmental toxicity of planar PCB congeners by egg injection
Conference
·
OSTI ID:242312
- National Biological Service, Laurel, MD (United States). Patuxent Environmental Science Center
The utility of egg injection studies for predicting potential embryotoxicity of PCBs and TCDD compares favorably with feeding studies. The effects of PCB congeners 3,3{prime}4,4{prime}-tetraCB (PCB 77), 2,3,3{prime},4,4{prime}-pentaCB (PCB 105), 3,3{prime},4,4{prime},5-pentaCB (PCB 126) and 2,2{prime},4,4{prime},5,5{prime}-hexaCB (PCB 153) were examined on embryonic development in chickens (Gallus gallus), northern bobwhite (Colinus virginianus), American kestrels (Falco sparverius), and common terns (Sterna hirundo) through hatching following air cell injections on day 4. The estimated LD{sub 50}s for these congeners in chickens were approximately 0.4 ppb, 2.6 ppb, 3326 ppb, and greater than 14,000 ppb, respectively; low effect levels (10--20% embryonic mortality) were 0.2 ppb, 1.2 ppb, 900 ppb, and 14,000 ppb respectively. The estimated LD{sub 50} for PCB 126 was 48 ppb for bobwhite, 65 ppb for American kestrels, and 104 ppb for common terns. The estimated LD{sub 50} for PCB 77 was 688 ppb for American kestrels. one or more hepatic microsomal cytochrome P450-linked monooxygenases including ethoxyresorufin-O-deethylase was assayed for each species. For PCB 126, the order of responsiveness of cytochrome P450 induction was: chicken > common tern > American kestrel > bobwhite, with chicken being approximately 100 times more responsive than common tern. These values are compared to existing Toxic Equivalency Factors (TEFs) including bioassay-derived ones.
- OSTI ID:
- 242312
- Report Number(s):
- CONF-9511137--; ISBN 1-880611-03-1
- Country of Publication:
- United States
- Language:
- English
Similar Records
Comparative developmental toxicity of planar polychlorinated biphenyl congeners in chickens, American kestrels, and common terns
Effects of 3,3{prime},4,4{prime}-tetrachlorobiphenyl, 2,3,3{prime},4,4{prime}-phntachlorobiphenyl, and 3,3{prime},4,4{prime},5-pentachlorobiphenyl on the developing chicken embryo when injected prior to incubation
Sensitivity of embryos of chicken, domestic duck, and common eider duck to polychlorinated and non-halogenated aromatic hydrocarbons
Journal Article
·
Tue Mar 31 23:00:00 EST 1998
· Environmental Toxicology and Chemistry
·
OSTI ID:675471
Effects of 3,3{prime},4,4{prime}-tetrachlorobiphenyl, 2,3,3{prime},4,4{prime}-phntachlorobiphenyl, and 3,3{prime},4,4{prime},5-pentachlorobiphenyl on the developing chicken embryo when injected prior to incubation
Journal Article
·
Fri Oct 25 00:00:00 EDT 1996
· Journal of Toxicology and Environmental Health
·
OSTI ID:394099
Sensitivity of embryos of chicken, domestic duck, and common eider duck to polychlorinated and non-halogenated aromatic hydrocarbons
Conference
·
Sat Dec 30 23:00:00 EST 1995
·
OSTI ID:242309