Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway

Ikeda, Zenichi; Kamei, Taku; Sasaki, Yusuke; Reynolds, Matthew; Sakai, Nozomu; Yoshikawa, Masato; Tawada, Michiko; Morishita, Nao; Dougan, Douglas R.; Chen, Chien-Hung; Levin, Irena; Zou, Hua; Kuno, Masako; Arimura, Naoto; Kikukawa, Yusuke; Kondo, Mitsuyo; Tohyama, Kimio; Sato, Kenjiro

doi:10.1021/acs.jmedchem.3c00348

Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway

Journal Article · Tue Apr 25 00:00:00 EDT 2023 · Journal of Medicinal Chemistry

DOI:https://doi.org/10.1021/acs.jmedchem.3c00348· OSTI ID:2422673

^[1]; Kamei, Taku ^[1]; Sasaki, Yusuke ^[1]; Reynolds, Matthew ^[1]; Sakai, Nozomu ^[1]; ^[1]; ^[1]; Morishita, Nao ^[1]; Dougan, Douglas R. ^[2]; Chen, Chien-Hung ^[2]; Levin, Irena ^[2]; Zou, Hua ^[2]; Kuno, Masako ^[1]; Arimura, Naoto ^[1]; Kikukawa, Yusuke ^[1]; Kondo, Mitsuyo ^[3]; Tohyama, Kimio ^[1]; Sato, Kenjiro ^[1]

Research, Takeda Pharmaceutical Company Ltd., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan
Structural Biology, Takeda Development Center Americas, Inc., San Diego, California 92121, United States
Discovery Biology, Discovery Science, Axcelead Drug Discovery Partners, Inc., 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-0012, Japan

Not provided.

Research Organization:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). Advanced Light Source (ALS)

Sponsoring Organization:: USDOE

DOE Contract Number:: AC02-05CH11231

OSTI ID:: 2422673

Journal Information:: Journal of Medicinal Chemistry, Journal Name: Journal of Medicinal Chemistry Journal Issue: 9 Vol. 66; ISSN 0022-2623

Publisher:: American Chemical Society (ACS)

Country of Publication:: United States

Language:: English

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