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The Effect of Prostate-Specific Antigen (PSA) Test on Radiation Risk Estimate for Prostate Cancer Incidence among Atomic-Bomb Survivors

Journal Article · · Radiation Research
 [1];  [2];  [3];  [2];  [2];  [2];  [2];  [4];  [2];  [4]
  1. Radiation Effects Research Foundation (RERF), Hiroshima (Japan); Radiation Effects Research Foundation (RERF), Nagasaki (Japan); Radiation Effects Research Foundation, Hiroshima (Japan)
  2. Radiation Effects Research Foundation (RERF), Hiroshima (Japan); Radiation Effects Research Foundation (RERF), Nagasaki (Japan)
  3. Hirosoft International, Eureka, CA (United States)
  4. National Institutes of Health (NIH), Bethesda, MD (United States). National Cancer Institute (NCI)
+ Show Author Affiliations
Following our previous report on the radiation doseresponse for prostate cancer incidence rates in the Life Span Study (LSS) cohort of atomic bomb survivors, we reevaluated the radiation-related risk adjusting for differences in baseline cancer incidence rates among three subsets of the LSS cohort defined by the timing of their first participation in biennial health examinations offered to the Adult Health Study (AHS) sub-cohort members and prostate-specificantigen (PSA) testing status for AHS participants: 1. nonAHS participants, 2. AHS participants before receiving PSA test, and 3. AHS participants after receiving PSA test. We found a 2.9-fold increase in the baseline incidence rates among AHS participants after receiving PSA test. After adjusting for the PSA-testing-status effects on the baseline rates the estimated excess relative risk (ERR) per Gy was 0.54 (95% CI: 0.15, 1.05), which was almost identical to the previously reported unadjusted ERR estimate (0.57, 95% CI: 0.21, 1.00). The current results confirmed that, while the PSA testing among AHS participants increased the baseline incidence rates, it did not impact the radiation risk estimate, strengthening the previously reported dose-response relationship for prostate cancer incidence in the LSS. As the use of PSA tests continue in screening and medical settings, analyses of possible effects of PSA testing should be an important aspect of future epidemiological studies of the association between radiation exposure and prostate cancer.
Research Organization:
National Academy of Sciences, Washington, DC (United States)
Sponsoring Organization:
National Institutes of Health (NIH); USDOE Office of Environment, Health, Safety and Security (AU)
Grant/Contract Number:
HS0000031
OSTI ID:
2418451
Journal Information:
Radiation Research, Journal Name: Radiation Research Journal Issue: 1 Vol. 200; ISSN 0033-7587
Publisher:
Radiation Research SocietyCopyright Statement
Country of Publication:
United States
Language:
English

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