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Restrictive spirometry pattern among construction trade workers

Journal Article · · American Journal of Industrial Medicine
DOI:https://doi.org/10.1002/ajim.23474· OSTI ID:2418442
 [1];  [2];  [3];  [4];  [5];  [5]
  1. University of Maryland, Baltimore, MD (United States). School of Medicine; OSTI
  2. Duke Univ., Durham, NC (United States). Medical Center
  3. University of Maryland, Baltimore, MD (United States). School of Medicine
  4. Zenith American Solutions, Covina, CA (United States)
  5. Center for Construction Research and Training (CPWR), Silver Spring, MD (United States)
+ Show Author Affiliations
Spirometry-based studies of occupational lung disease have mostly focused on obstructive or mixed obstructive/restrictive outcomes. We wanted to determine if restrictive spirometry pattern (RSP) is associated with occupation and increased mortality. Study participants included 18,145 workers with demographic and smoking data and repeatable spirometry. The mortality analysis cohort included 15,445 workers with known vital status and cause of death through December 31, 2016. Stratified analyses explored RSP prevalence by demographic and clinical variables and trade. Log-binomial regression models explored RSP risk factors while controlling for important confounders such as smoking, obesity, and comorbidities. Cox regression models explored mortality risk by spirometry category. Prevalence of RSP was very high (28.6%). Mortality hazard ratios for RSP were 1.50 for all causes, 1.86 for cardiovascular diseases, 2.31 for respiratory diseases, and 1.66 for lung cancer. All construction trades except painters, machinists, and roofers had significantly elevated risk for RSP compared to our internal reference group. RSP was significantly associated with both parenchymal and pleural changes seen by chest X-ray. Construction trade workers are at significantly increased risk for RSP independent of obesity. Individuals with RSP are at increased risk for all-cause mortality as well as mortality attributable to respiratory diseases, cardiovascular diseases, and lung cancer. RSP deserves greater attention in occupational medicine and epidemiology.
Research Organization:
Center for Construction Research and Training (CPWR), Silver Spring, MD (United States)
Sponsoring Organization:
USDOE
Grant/Contract Number:
FC01-06EH06004
OSTI ID:
2418442
Alternate ID(s):
OSTI ID: 1962695
Journal Information:
American Journal of Industrial Medicine, Journal Name: American Journal of Industrial Medicine Journal Issue: 6 Vol. 66; ISSN 0271-3586
Publisher:
WileyCopyright Statement
Country of Publication:
United States
Language:
English

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Related Subjects

60 APPLIED LIFE SCIENCES
construction trades
mortality
parenchymal
pleural
restrictive spirometry pattern