Physical and genetic localization of a shab subfamily potassium channel (KCNB1) gene to chromosomal region 20q13.2
- Univ. of Utah, Salt Lake City, UT (United States); and others
A human delayed rectifier K{sup +} channel gene has been localized to the long arm of human chromosome 20q13.2 by fluorescence in situ hybridization of genomic P1 clones from this locus. A polymorphic (GA) microsatellite repeat was identified in one of the P1 clones. The new SSR marker (D20S436) was genotyped in four CEPH pedigrees. Two-point linkage analysis indicated linkage of this marker to a PCR marker, D20S109, with a maximum lod score of 9.32 at {theta} = 0.001. The assignment of this K{sup +} channel gene to 20q13.2 eliminates it as a candidate for the gene associated with benign familial neonatal convulsions (BFNC), which has been localized to 20q13.3. Genetically, the K{sup +} channel gene maps more than 30 cM proximal to the BFNC locus. 16 refs., 1 fig., 1 tab.
- OSTI ID:
- 241091
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 1 Vol. 25; ISSN 0888-7543; ISSN GNMCEP
- Country of Publication:
- United States
- Language:
- English
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