No increase in female recombination frequency in the distal part of the human pseudoautosomal region
- Institut de Biologie, Nantes (France)
In human, the genetic map is larger in female than in male. However, for unknown reasons, a reversed situation is observed toward at least some telomeres, where recombination in males can be 10-fold that observed in females. Henke et al. report that male and female recombination rates are equal in the very distal part of the human pseudoautosomal region (PAR), thus suggesting that the telomeric excess of male recombination, when observed, may not exist right to the tip of chromosomes. Such an observation is of importance for the genetic mapping of chromosome ends, for both practical and biological reasons. Thus, I have examined in detail our own data for this region and failed to confirm the previous report. I will explain here the origin of the discrepancy, in the CEPH family K1333 presented in detail in the Henke et al. report, which accounts for half (3/6) of the maternal recombination events detected in the most distal interval of the PAR. 9 refs., 1 fig.
- OSTI ID:
- 241055
- Journal Information:
- Genomics, Journal Name: Genomics Journal Issue: 3 Vol. 24; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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