Physical mapping of genetic markers on the short arm of chromosome 5

Journal Article · Thu Dec 01 04:00:00 EST 1994 · Genomics

DOI:https://doi.org/10.1006/geno.1994.1668· OSTI ID:241044

Gersh, M; Goodart, S A; Overhauser, J ^[1]

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1. Thomas Jefferson Univ., Philadelphia, PA (United States)

The deletion of the short arm of chromosome 5 is associated with the cri-du-chat syndrome. In addition, loss of this portion of a chromosome is a common cytogenetic marker in a number of malignancies. However, to date, no genes associated with these disorders have been identified. Physical maps are the first step in isolating causative genes, and genes involved in autosomal recessive disorders are now routinely mapped through the identification of linked markers. Extensive genetic maps based upon polymorphic short tandem repeats (STRs) have provided researchers with a large number of markers to which such disorders can be genetically mapped. However, the physical locations of many of these STRs have not been determined. Toward the goal of integrating the human genetic maps with the physical maps, a 5p somatic cell hybrid deletion mapping panel that was derived from patients with 5p deletions or translocations was used to physically map 47 STRs that have been used to construct genetic maps of 5p. These data will be useful in the localization of disease genes that map to 5p and may be involved in the etiology of the cri-du-chat syndrome. 26 refs., 1 fig.

• OSTI ID: 241044
• Journal Information: Genomics, Journal Name: Genomics Journal Issue: 3 Vol. 24; ISSN 0888-7543; ISSN GNMCEP
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
BIOLOGICAL MARKERS
CHROMOSOMAL ABERRATIONS
ETIOLOGY
GENES
GENETIC MAPPING
HEREDITARY DISEASES
HUMAN CHROMOSOME 5
HYBRIDIZATION
PATIENTS
POLYMERASE CHAIN REACTION
RECESSIVE MUTATIONS
SOMATIC CELLS