Multi-scale signaling and tumor evolution in high-grade gliomas

Liu, Jingxian; Cao, Song; Imbach, Kathleen J.; Gritsenko, Marina A.; Lih, Tung-Shing M.; Kyle, Jennifer E.; Yaron-Barir, Tomer M.; Binder, Zev A.; Li, Yize; Strunilin, Ilya; Wang, Yi-Ting; Tsai, Chia-Feng; Ma, Weiping; Chen, Lijun; Clark, Natalie M.; Shinkle, Andrew; Naser Al Deen, Nataly; Caravan, Wagma; Houston, Andrew; Simin, Faria Anjum; Wyczalkowski, Matthew A.; Wang, Liang-Bo; Storrs, Erik; Chen, Siqi; Illindala, Ritvik; Li, Yuping D.; Jayasinghe, Reyka G.; Rykunov, Dmitry; Cottingham, Sandra L.; Chu, Rosalie K.; Weitz, Karl K.; Moore, Ronald J.; Sagendorf, Tyler; Petyuk, Vladislav A.; Nestor, Michael; Bramer, Lisa M.; Stratton, Kelly G.; Schepmoes, Athena A.; Couvillion, Sneha P.; Eder, Josie; Kim, Young-Mo; Gao, Yuqian; Fillmore, Thomas L.; Zhao, Rui; Monroe, Matthew E.; Southard-Smith, Austin N.; Li, Yang E.; Jui-Hsien Lu, Rita; Johnson, Jared L.; Wiznerowicz, Maciej; Hostetter, Galen; Newton, Chelsea J.; Ketchum, Karen A.; Thangudu, Ratna R.; Barnholtz-Sloan, Jill S.; Wang, Pei; Fenyö, David; An, Eunkyung; Thiagarajan, Mathangi; Robles, Ana I.; Mani, D. R.; Smith, Richard D.; Porta-Pardo, Eduard; Cantley, Lewis C.; Iavarone, Antonio; Chen, Feng; Mesri, Mehdi; Nasrallah, MacLean P.; Zhang, Hui; Resnick, Adam C.; Chheda, Milan G.; Rodland, Karin D.; Liu, Tao; Ding, Li

doi:10.1016/j.ccell.2024.06.004

Multi-scale signaling and tumor evolution in high-grade gliomas

Journal Article · Mon Jul 08 00:00:00 EDT 2024 · Cancer Cell

DOI:https://doi.org/10.1016/j.ccell.2024.06.004· OSTI ID:2406583

Liu, Jingxian ^[1]; Cao, Song; Imbach, Kathleen J.; Gritsenko, Marina A.; Lih, Tung-Shing M.; Kyle, Jennifer E.; Yaron-Barir, Tomer M.; Binder, Zev A.; Li, Yize; Strunilin, Ilya; Wang, Yi-Ting; Tsai, Chia-Feng; Ma, Weiping; Chen, Lijun; Clark, Natalie M.; Shinkle, Andrew; Naser Al Deen, Nataly; Caravan, Wagma; Houston, Andrew; Simin, Faria Anjum more »

Washington Univ., St. Louis, MO (United States); et al.

Although genomic anomalies in glioblastoma (GBM) have been well studied for over a decade, its 5-year survival rate remains lower than 5%. We seek to expand the molecular landscape of high-grade glioma, composed of IDH-wildtype GBM and IDH-mutant grade 4 astrocytoma, by integrating proteomic, metabolomic, lipidomic, and post-translational modifications (PTMs) with genomic and transcriptomic measurements to uncover multi-scale regulatory interactions governing tumor development and evolution. Applying 14 proteogenomic and metabolomic platforms to 228 tumors (212 GBM and 16 grade 4 IDH-mutant astrocytoma), including 28 at recurrence, plus 18 normal brain samples and 14 brain metastases as comparators, reveals heterogeneous upstream alterations converging on common downstream events at the proteomic and metabolomic levels and changes in protein-protein interactions and glycosylation site occupancy at recurrence. Recurrent genetic alterations and phosphorylation events on PTPN11 map to important regulatory domains in three dimensions, suggesting a central role for PTPN11 signaling across high-grade gliomas.

View Accepted Manuscript (DOE)

Research Organization:: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Organization:: USDOE

Contributing Organization:: Philadelphia Coalition for a Cure

Grant/Contract Number:: AC05-76RL01830

OSTI ID:: 2406583

Report Number(s):: PNNL-SA--189873

Journal Information:: Cancer Cell, Journal Name: Cancer Cell Journal Issue: 7 Vol. 42; ISSN 1535-6108

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Analysis of p53 mutation and epidermal growth factor receptor amplification in recurrent gliomas with malignant progression

Journal Article · Mon Jul 01 00:00:00 EDT 1996 · Journal of Neuropathology and Experimental Neurology · OSTI ID:508622

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60 APPLIED LIFE SCIENCES
CPTAC
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single nuclei RNA-seq
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