New Onset Type 1 Diabetes Urine Metabolomics

Dataset · Mon Jul 22 04:00:00 EDT 2024

DOI:https://doi.org/10.25584/2405140· OSTI ID:2405140

Bramer, Lisa ^[1]; Webb-Robertson, Bobbie-Jo M ^[2]; Flores, Javier ^[2]

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1. Pacific Northwest National Laboratory (PNNL), Richland, WA (United States); PNNL
2. Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Gas chromatography-mass spectrometry-based metabolomics to identify molecular signatures of Type 1 Diabetes (T1D) in urine. We utilize three cohorts in different stages post-diagnosis: (1) new onset, (2) within one year of diagnosis and (3) after 6 years of diagnosis. There were 91 metabolites identified in all three datasets with complete data represented in each cohort dataset. Cohort 1 (CNMC): 32 T1D cases; 32 healthy controls siblings Cohort 2 (BDCD): 27 T1D cases; 27 healthy controls siblings Cohort 3 (IUSOM): 12 T1D cases; 20 healthy controls Cases and controls matched on sex and age

• Research Organization: Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
• Sponsoring Organization: USDOE Office of Science (SC)
• DOE Contract Number: AC05-76RL01830
• OSTI ID: 2405140
• Country of Publication: United States
• Language: English