Bioadhesive polymer semiconductors and transistors for intimate biointerfaces

Li, Nan; Li, Yang; Cheng, Zhe; Liu, Youdi; Dai, Yahao; Kang, Seounghun; Li, Songsong; Shan, Naisong; Wai, Shinya; Ziaja, Aidan; Wang, Yunfei; Strzalka, Joseph; Liu, Wei; Zhang, Cheng; Gu, Xiaodan; Hubbell, Jeffrey A.; Tian, Bozhi; Wang, Sihong

doi:10.1126/science.adg8758

Bioadhesive polymer semiconductors and transistors for intimate biointerfaces

Journal Article · Thu Aug 10 00:00:00 EDT 2023 · Science

DOI:https://doi.org/10.1126/science.adg8758· OSTI ID:2404843

^[1]; ^[1]; Cheng, Zhe ^[1]; Liu, Youdi ^[1]; ^[1]; ^[1]; ^[1]; ^[1]; ^[1]; Ziaja, Aidan ^[1]; ^[2]; ^[3]; ^[1]; ^[1]; ^[2]; ^[1]; ^[1]; ^[4]

Univ. of Chicago, IL (United States)
Univ. of Southern Mississippi, Hattiesburg, MS (United States)
Argonne National Laboratory (ANL), Argonne, IL (United States)
Univ. of Chicago, IL (United States); Argonne National Laboratory (ANL), Argonne, IL (United States)

The use of bioelectronic devices relies on direct contact with soft biotissues. For transistor-type bioelectronic devices, the semiconductors that need to have direct interfacing with biotissues for effective signal transduction do not adhere well with wet tissues, thereby limiting the stability and conformability at the interface. Here we report a bioadhesive polymer semiconductor through a double-network structure formed by a bioadhesive brush polymer and a redox-active semiconducting polymer. The resulting semiconducting film can form rapid and strong adhesion with wet tissue surfaces together with high charge-carrier mobility of ~1 square centimeter per volt per second, high stretchability, and good biocompatibility. Further fabrication of a fully bioadhesive transistor sensor enabled us to produce high-quality and stable electrophysiological recordings on an isolated rat heart and in vivo rat muscles.

View Accepted Manuscript (DOE)

Research Organization:: Argonne National Laboratory (ANL), Argonne, IL (United States)

Sponsoring Organization:: National Institute of Health (NIH); National Science Foundation (NSF); US Department of the Navy, Office of Naval Research (ONR); USDOE Office of Science (SC), Basic Energy Sciences (BES)

Grant/Contract Number:: AC02-06CH11357

OSTI ID:: 2404843

Journal Information:: Science, Journal Name: Science Journal Issue: 6658 Vol. 381; ISSN 0036-8075

Publisher:: AAASCopyright Statement

Country of Publication:: United States

Language:: English

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