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MiNAA: Microbiome Network Alignment Algorithm

Journal Article · · Journal of Open Source Software
DOI:https://doi.org/10.21105/joss.05448· OSTI ID:2395884
 [1];  [2];  [2]
  1. Univ. of Wisconsin, Madison, WI (United States); University of Wisconsin-Madison Department of Plant Pathology
  2. Univ. of Wisconsin, Madison, WI (United States)
A microbial network is a mathematical representation of a microbial community where nodes represent microbes and edges represent interactions. It is well-recognized that microbes are among the main drivers of biological phenotypes in soil, plants, and animals alike, and thus, their study has vast implications for soil, plant and human health. In particular, recognizing the microbial, environmental, and agricultural factors that drive plant and soil phenotypes is crucial to comprehend processes connected to plant and soil health, to identify global practices of sustainable agriculture, as well as to predict plant and soil responses to environmental perturbations such as climate change. The adaptability of microbes to thrive in every environment poses challenges for scientists who try to understand their communities. Indeed, two microbial communities with the exact same players can interact differently depending on the environmental conditions. It is thus desirable to identify commonalities and differences on two microbial networks, hence the need for computational tools that can match (or align) them.
Research Organization:
Univ. of Wisconsin, Madison, WI (United States)
Sponsoring Organization:
USDOE Office of Science (SC), Biological and Environmental Research (BER)
Grant/Contract Number:
SC0021016
OSTI ID:
2395884
Journal Information:
Journal of Open Source Software, Journal Name: Journal of Open Source Software Journal Issue: 96 Vol. 9; ISSN 2475-9066
Publisher:
Open Source Initiative - NumFOCUSCopyright Statement
Country of Publication:
United States
Language:
English

References (14)

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NETAL: a new graph-based method for global alignment of protein–protein interaction networks journal May 2013
L-GRAAL: Lagrangian graphlet-based network aligner journal February 2015
Topological network alignment uncovers biological function and phylogeny journal March 2010
GPPIAL: A New Global PPI Network Aligner Based on Orthologs conference December 2020
GraphCrunch 2: Software tool for network modeling, alignment and clustering journal January 2011
Meta-network: optimized species-species network analysis for microbial communities journal April 2019
Tutorial on Implementation of Munkres' Assignment Algorithm null January 1995
Sparse and Compositionally Robust Inference of Microbial Ecological Networks journal May 2015
Computation of Graphlet Orbits for Nodes and Edges in Sparse Graphs journal January 2016
Uncovering Biological Network Function via Graphlet Degree Signatures journal January 2008
Meta-network: optimized species-species network analysis for microbial communities collection January 2019

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