Discrimination of Mild Cognitive Impairment and Alzheimer′s Disease Using Transfer Entropy Measures of Scalp EEG

McBride, Joseph; Zhao, Xiaopeng; Munro, Nancy; Jicha, Gregory; Smith, Charles; Jiang, Yang

doi:10.1260/2040-2295.6.1.55

Discrimination of Mild Cognitive Impairment and Alzheimer′s Disease Using Transfer Entropy Measures of Scalp EEG

Journal Article · Mon Feb 23 00:00:00 EST 2015 · Journal of Healthcare Engineering

DOI:https://doi.org/10.1260/2040-2295.6.1.55· OSTI ID:2370563

McBride, Joseph; Zhao, Xiaopeng; Munro, Nancy; Jicha, Gregory; Smith, Charles; Jiang, Yang

Mild cognitive impairment (MCI) is a neurological condition related to early stages of dementia including Alzheimer′s disease (AD). This study investigates the potential of measures of transfer entropy in scalp EEG for effectively discriminating between normal aging, MCI, and AD participants. Resting EEG records from 48 age‐matched participants (mean age 75.7 years)—15 normal controls, 16 MCI, and 17 early AD—are examined. The mean temporal delays corresponding to peaks in inter‐regional transfer entropy are computed and used as features to discriminate between the three groups of participants. Three‐way classification schemes based on binary support vector machine models demonstrate overall discrimination accuracies of 91.7— 93.8%, depending on the protocol condition. These results demonstrate the potential for EEG transfer entropy measures as biomarkers in identifying early MCI and AD. Moreover, the analyses based on short data segments (two minutes) render the method practical for a primary care setting.

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Sponsoring Organization:: USDOE

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 2370563

Journal Information:: Journal of Healthcare Engineering, Journal Name: Journal of Healthcare Engineering Journal Issue: 1 Vol. 6; ISSN 2040-2295

Publisher:: Hindawi Publishing CorporationCopyright Statement

Country of Publication:: Country unknown/Code not available

Language:: English

References (31)

Current Concepts in Mild Cognitive Impairment Petersen, Ronald C.; Doody, Rachelle; Kurz, Alexander Archives of Neurology, Vol. 58, Issue 12 https://doi.org/10.1001/archneur.58.12.1985	journal	December 2001
Nonparametric permutation tests for functional neuroimaging: A primer with examples Nichols, Thomas E.; Holmes, Andrew P. Human Brain Mapping, Vol. 15, Issue 1 https://doi.org/10.1002/hbm.1058	journal	November 2001
Resting EEG Discrimination of Early Stage Alzheimer’s Disease from Normal Aging Using Inter-Channel Coherence Network Graphs McBride, Joseph; Zhao, Xiaopeng; Munro, Nancy Annals of Biomedical Engineering, Vol. 41, Issue 6 https://doi.org/10.1007/s10439-013-0788-4	journal	March 2013
Transfer entropy—a model-free measure of effective connectivity for the neurosciences Vicente, Raul; Wibral, Michael; Lindner, Michael Journal of Computational Neuroscience, Vol. 30, Issue 1 https://doi.org/10.1007/s10827-010-0262-3	journal	August 2010
Multivariate information-theoretic measures reveal directed information structure and task relevant changes in fMRI connectivity Lizier, Joseph T.; Heinzle, Jakob; Horstmann, Annette Journal of Computational Neuroscience, Vol. 30, Issue 1 https://doi.org/10.1007/s10827-010-0271-2	journal	August 2010
Discrimination of Alzheimer's disease and mild cognitive impairment by equivalent EEG sources: a cross-sectional and longitudinal study Huang, C.; Wahlund, L. -O; Dierks, T. Clinical Neurophysiology, Vol. 111, Issue 11 https://doi.org/10.1016/S1388-2457(00)00454-5	journal	November 2000
Tau pathology in Alzheimer disease and other tauopathies Iqbal, Khalid; del C. Alonso, Alejandra; Chen, She Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1739, Issue 2-3 https://doi.org/10.1016/j.bbadis.2004.09.008	journal	January 2005
Disturbed fluctuations of resting state EEG synchronization in Alzheimer's disease Stam, C. J.; Montez, T.; Jones, B. F. Clinical Neurophysiology, Vol. 116, Issue 3 https://doi.org/10.1016/j.clinph.2004.09.022	journal	March 2005
Spectral and complexity analysis of scalp EEG characteristics for mild cognitive impairment and early Alzheimer's disease McBride, Joseph C.; Zhao, Xiaopeng; Munro, Nancy B. Computer Methods and Programs in Biomedicine, Vol. 114, Issue 2 https://doi.org/10.1016/j.cmpb.2014.01.019	journal	April 2014
Speed of lexical decision correlates with diffusion anisotropy in left parietal and frontal white matter: Evidence from diffusion tensor imaging Gold, Brian T.; Powell, David K.; Xuan, Liang Neuropsychologia, Vol. 45, Issue 11 https://doi.org/10.1016/j.neuropsychologia.2007.04.011	journal	January 2007
Conversion from mild cognitive impairment to Alzheimer’s disease is predicted by sources and coherence of brain electroencephalography rhythms Rossini, P. M.; Del Percio, C.; Pasqualetti, P. Neuroscience, Vol. 143, Issue 3 https://doi.org/10.1016/j.neuroscience.2006.08.049	journal	December 2006
Sugihara causality analysis of scalp EEG for detection of early Alzheimer's disease McBride, Joseph C.; Zhao, Xiaopeng; Munro, Nancy B. NeuroImage: Clinical, Vol. 7 https://doi.org/10.1016/j.nicl.2014.12.005	journal	January 2015
The Tsallis entropy of natural information Sneddon, Robert Physica A: Statistical Mechanics and its Applications, Vol. 386, Issue 1 https://doi.org/10.1016/j.physa.2007.05.065	journal	December 2007
Causality detection based on information-theoretic approaches in time series analysis Hlavackovaschindler, K.; Palus, M.; Vejmelka, M. Physics Reports, Vol. 441, Issue 1 https://doi.org/10.1016/j.physrep.2006.12.004	journal	March 2007
EEG synchronization in mild cognitive impairment and Alzheimer's disease: EEG synchronization in MCI and AD Stam, C. J.; Van Der Made, Y.; Pijnenburg, Y. A. L. Acta Neurologica Scandinavica, Vol. 108, Issue 2 https://doi.org/10.1034/j.1600-0404.2003.02067.x	journal	July 2003
Small-World Networks and Functional Connectivity in Alzheimer's Disease Stam, C.; Jones, B.; Nolte, G. Cerebral Cortex, Vol. 17, Issue 1 https://doi.org/10.1093/cercor/bhj127	journal	February 2006
Granger Causality and Transfer Entropy Are Equivalent for Gaussian Variables Barnett, Lionel; Barrett, Adam B.; Seth, Anil K. Physical Review Letters, Vol. 103, Issue 23 https://doi.org/10.1103/PhysRevLett.103.238701	journal	December 2009
Measuring Information Transfer Schreiber, Thomas Physical Review Letters, Vol. 85, Issue 2 https://doi.org/10.1103/PhysRevLett.85.461	journal	July 2000
Characterization of EEGs in Alzheimer's Disease using Information Theoretic Methods Zhao, Peng; Van-Eetvelt, Peter; Goh, Cindy 2007 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society https://doi.org/10.1109/IEMBS.2007.4353494	conference	August 2007
Scalp EEG-Based Discrimination of Cognitive Deficits After Traumatic Brain Injury Using Event-Related Tsallis Entropy Analysis McBride, J.; Zhao, X.; Nichols, T. IEEE Transactions on Biomedical Engineering, Vol. 60, Issue 1 https://doi.org/10.1109/TBME.2012.2223698	journal	January 2013
Differentiating information transfer and causal effect Lizier, J. T.; Prokopenko, M. The European Physical Journal B, Vol. 73, Issue 4 https://doi.org/10.1140/epjb/e2010-00034-5	journal	January 2010
Sample entropy analysis of neonatal heart rate variability Lake, Douglas E.; Richman, Joshua S.; Griffin, M. Pamela American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 283, Issue 3 https://doi.org/10.1152/ajpregu.00069.2002	journal	September 2002
Tau Pathology and Parietal White Matter Lesions Have Independent but Synergistic Effects on Early Development of Alzheimer's Disease Hertze, Joakim; Palmqvist, Sebastian; Minthon, Lennart Dementia and Geriatric Cognitive Disorders Extra, Vol. 3, Issue 1 https://doi.org/10.1159/000348353	journal	April 2013
EEG Detection of Early Alzheimer's Disease Using Psychophysical Tasks Sneddon, Robert; Shankle, William Rodman; Hara, Junko Clinical EEG and Neuroscience, Vol. 36, Issue 3 https://doi.org/10.1177/155005940503600304	journal	July 2005
Evidence-Based Evaluation of Diagnostic Accuracy of Resting EEG in Dementia and Mild Cognitive Impairment Jelic, Vesna; Kowalski, Jan Clinical EEG and Neuroscience, Vol. 40, Issue 2 https://doi.org/10.1177/155005940904000211	journal	April 2009
Classification by pairwise coupling Hastie, Trevor; Tibshirani, Robert The Annals of Statistics, Vol. 26, Issue 2 https://doi.org/10.1214/aos/1028144844	journal	April 1998
Measuring Information-Transfer Delays Wibral, Michael; Pampu, Nicolae; Priesemann, Viola PLoS ONE, Vol. 8, Issue 2 https://doi.org/10.1371/journal.pone.0055809	journal	February 2013
Diagnosis of Alzheimers Disease from EEG Signals: Where Are We Standing? Dauwels, J.; Vialatte, F.; Cichocki, A. Current Alzheimer Research, Vol. 7, Issue 6 https://doi.org/10.2174/156720510792231720	journal	September 2010
University of Kentucky Sanders-Brown Healthy Brain Aging Volunteers: Donor Characteristics, Procedures and Neuropathology A. Schmitt, Frederick; T. Nelson, Peter; Abner, Erin Current Alzheimer Research, Vol. 9, Issue 6 https://doi.org/10.2174/156720512801322591	journal	June 2012
EEG Patterns in Mild Cognitive Impairment (MCI) Patients Baker, Mary; Akrofi, Kwaku; Schiffer, Randolph The Open Neuroimaging Journal, Vol. 2 https://doi.org/10.2174/1874440000802010052	journal	August 2008
Two Challenges of Correct Validation in Pattern Recognition Nowotny, Thomas Frontiers in Robotics and AI, Vol. 1 https://doi.org/10.3389/frobt.2014.00005	journal	September 2014

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