Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering

Kučerka, Norbert; Heberle, Frederick; Pan, Jianjun; Katsaras, John

doi:10.3390/membranes5030454

Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering

Journal Article · Mon Sep 21 00:00:00 EDT 2015 · Membranes

DOI:https://doi.org/10.3390/membranes5030454· OSTI ID:2369825

Kučerka, Norbert; Heberle, Frederick; Pan, Jianjun; Katsaras, John

We review recent developments in the rapidly growing field of membrane biophysics, with a focus on the structural properties of single lipid bilayers determined by different scattering techniques, namely neutron and X-ray scattering. The need for accurate lipid structural properties is emphasized by the sometimes conflicting results found in the literature, even in the case of the most studied lipid bilayers. Increasingly, accurate and detailed structural models require more experimental data, such as those from contrast varied neutron scattering and X-ray scattering experiments that are jointly refined with molecular dynamics simulations. This experimental and computational approach produces robust bilayer structural parameters that enable insights, for example, into the interplay between collective membrane properties and its components (e.g., hydrocarbon chain length and unsaturation, and lipid headgroup composition). From model studies such as these, one is better able to appreciate how a real biological membrane can be tuned by balancing the contributions from the lipid’s different moieties (e.g., acyl chains, headgroups, backbones, etc.).

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Research Organization:: Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: Joint Inst. for Nuclear Research (JINR) (Russian Federation); Ministry of Education, Science, Research and Sport of the Slovak Republic (Slovakia); USDOE; USDOE Office of Science (SC), Basic Energy Sciences (BES) (SC-22)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 2369825

Alternate ID(s):: OSTI ID: 1265608

Journal Information:: Membranes, Journal Name: Membranes Journal Issue: 3 Vol. 5; ISSN 2077-0375; ISSN MBSEB6

Publisher:: MDPI AGCopyright Statement

Country of Publication:: Switzerland

Language:: English

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X-ray scattering
bilayer
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Structural Significance of Lipid Diversity as Studied by Small Angle Neutron and X-ray Scattering

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