Skip to main content
U.S. Department of Energy
Office of Scientific and Technical Information

Synthesis and Evaluation of diaryl ether modulators of the leukotriene A4 hydrolase aminopeptidase activity

Journal Article · · European Journal of Medicinal Chemistry

Not Available

Sponsoring Organization:
USDOE
Grant/Contract Number:
AC02-06CH11357
OSTI ID:
2346244
Journal Information:
European Journal of Medicinal Chemistry, Journal Name: European Journal of Medicinal Chemistry Journal Issue: C Vol. 272; ISSN 0223-5234
Publisher:
ElsevierCopyright Statement
Country of Publication:
France
Language:
English

References (35)

Efficient and General One-Pot Synthesis of Diaryliodonium Triflates: Optimization, Scope and Limitations journal December 2007
Trimethoxyphenyl (TMP) as a Useful Auxiliary for in situ Formation and Reaction of Aryl(TMP)iodonium Salts: Synthesis of Diaryl Ethers journal November 2019
Significantly Improved Method for the Pd-Catalyzed Coupling of Phenols with Aryl Halides: Understanding Ligand Effects journal June 2006
Radical Catalysis of Kumada Cross‐Coupling Reactions Using Functionalized Grignard Reagents journal December 2008
In Vitro Drug Metabolism Using Liver Microsomes journal September 2016
Synthesis, characterization, biological activity, and 3D-QSAR studies on some novel class of pyrrole derivatives as antitubercular agents journal August 2013
Effect of the leukotriene A4 hydrolase aminopeptidase augmentor 4-methoxydiphenylmethane in a pre-clinical model of pulmonary emphysema journal November 2011
New and promising type of leukotriene B4 (LTB4) antagonists based on the 1,4-benzodioxine structure journal June 2023
Synthesis of β-ketonitriles, α,β-alkynones and biscabinols from esters using tert-butoxide-assisted C(O)–C (i.e., acyl–C) coupling under ambient conditions journal December 2013
Discovery of Amino Alcohols as Highly Potent, Selective, and Orally Efficacious Inhibitors of Leukotriene A4 Hydrolase journal November 2023
Effect of Modifier Structure on the Activation of Leukotriene A4 Hydrolase Aminopeptidase Activity journal November 2019
An Efficient and Expeditious Synthesis of Di- and Monosubstituted 2-Aminoimidazoles journal January 2008
Hydrocarbon Hydroxylation by Cytochrome P450 Enzymes journal February 2010
Pd-Catalyzed Kumada−Corriu Cross-Coupling Reactions at Low Temperatures Allow the Use of Knochel-type Grignard Reagents journal March 2007
An Improved Catalyst System for Aromatic Carbon−Nitrogen Bond Formation:  The Possible Involvement of Bis(Phosphine) Palladium Complexes as Key Intermediates journal January 1996
Discovery, Synthesis, and Optimization of Antimalarial 4(1 H )-Quinolone-3-Diarylethers journal April 2014
Microwave-Assisted Protection of Primary Amines as 2,5-Dimethylpyrroles and Their Orthogonal Deprotection journal October 2013
N,N-Dimethyl Glycine-Promoted Ullmann Coupling Reaction of Phenols and Aryl Halides journal September 2003
Room Temperature, Metal-Free Synthesis of Diaryl Ethers with Use of Diaryliodonium Salts journal February 2011
Cytochrome P450-Mediated Epoxidation of 2-Aminothiazole-Based AKT Inhibitors: Identification of Novel GSH Adducts and Reduction of Metabolic Activation through Structural Changes Guided by in Silico and in Vitro Screening journal January 2010
Feasibility and physiological relevance of designing highly potent aminopeptidase-sparing leukotriene A4 hydrolase inhibitors journal October 2017
Substrate-dependent modulation of the leukotriene A4 hydrolase aminopeptidase activity and effect in a murine model of acute lung inflammation journal June 2022
Direct synthesis of pyrazoles from esters using tert-butoxide-assisted C–(CO) coupling journal January 2015
Binding of Pro-Gly-Pro at the active site of leukotriene A 4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor journal March 2014
A Critical Role for LTA4H in Limiting Chronic Pulmonary Neutrophilic Inflammation journal September 2010
Increased leukotriene B4 and 8-isoprostane in exhaled breath condensate of patients with exacerbations of COPD journal April 2003
Role of LTB4in the pathogenesis of elastase-induced murine pulmonary emphysema journal December 2010
Hepcidin-mediated iron sequestration protects against bacterial dissemination during pneumonia journal March 2017
N-α-PGP and PGP, potential biomarkers and therapeutic targets for COPD journal May 2009
Marked elevations in pro-inflammatory polyunsaturated fatty acid metabolites in females with irritable bowel syndrome journal May 2010
Treatment with DHA/EPA ameliorates atopic dermatitis-like skin disease by blocking LTB4 production journal January 2016
Synthesis of pyrazolopyrimidinones using a “one-pot” approach under microwave irradiation journal May 2018
Role of Leukotriene A4 Hydrolase Aminopeptidase in the Pathogenesis of Emphysema journal June 2014
Leukotriene-deficient mice manifest enhanced lethality from Klebsiella pneumonia in association with decreased alveolar macrophage phagocytic and bactericidal activities. journal December 1996
M-CSF Mediates Host Defense during Bacterial Pneumonia by Promoting the Survival of Lung and Liver Mononuclear Phagocytes journal June 2016

Similar Records

Design and synthesis of Leukotriene A4 hydrolase inhibitors to alleviate idiopathic pulmonary fibrosis and acute lung injury
Journal Article · Thu Oct 01 00:00:00 EDT 2020 · European Journal of Medicinal Chemistry · OSTI ID:2279999

Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography
Journal Article · Wed Dec 31 23:00:00 EST 2008 · Journal of Medicinal Chemistry · OSTI ID:980158

Kinetics of leukotriene A4 synthesis by 5-lipoxygenase from rat polymorphonuclear leukocytes
Journal Article · Tue Sep 08 00:00:00 EDT 1987 · Biochemistry; (United States) · OSTI ID:5724605

Related Subjects