Biosystem&nbsp;design of Corynebacterium glutamicum for bioproduction

Zha, Jian; Zhao, Zhen; Xiao, Zhengyang; Eng, Thomas; Mukhopadhyay, Aindrila; Koffas, Mattheos AG; Tang, Yinjie J.

doi:10.1016/j.copbio.2022.102870

Biosystem design of Corynebacterium glutamicum for bioproduction

Journal Article · Tue Dec 20 00:00:00 EST 2022 · Current Opinion in Biotechnology

DOI:https://doi.org/10.1016/j.copbio.2022.102870· OSTI ID:2323906

Zha, Jian ^[1]; Zhao, Zhen ^[1]; Xiao, Zhengyang ^[2]; Eng, Thomas ^[3]; Mukhopadhyay, Aindrila ^[3]; Koffas, Mattheos AG ^[4]; Tang, Yinjie J. ^[2]

Shaanxi University of Science and Technology, Xi'an, Shaanxi (China)
Washington Univ., St. Louis, MO (United States)
Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
Rensselaer Polytechnic Inst., Troy, NY (United States)

Corynebacterium glutamicum, a natural glutamate-producing bacterium adopted for industrial production of amino acids, has been extensively explored recently for high-level biosynthesis of amino acid derivatives, bulk chemicals such as organic acids and short-chain alcohols, aromatics, and natural products, including polyphenols and terpenoids. Here, we review the recent advances with a focus on biosystem design principles, metabolic characterization and modeling, omics analysis, utilization of nonmodel feedstock, emerging CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) tools for Corynebacterium strain engineering, biosensors, and novel strains of C. glutamicum. Further, future research directions for developing C. glutamicum cell factories are also discussed.

View Accepted Manuscript (DOE)

Research Organization:: Joint BioEnergy Institute (JBEI), Emeryville, CA (United States); Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Organization:: National Science Foundation (NSF); USDOE; USDOE Office of Science (SC)

Grant/Contract Number:: AC02-05CH11231

OSTI ID:: 2323906

Alternate ID(s):: OSTI ID: 1906760

Journal Information:: Current Opinion in Biotechnology, Journal Name: Current Opinion in Biotechnology Vol. 79; ISSN 0958-1669

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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