PI3Kαδ Inhibitor Combined With Radiation Enhances the Antitumor Immune Effect of Anti-PD1 in a Syngeneic Murine Triple-Negative Breast Cancer Model

Journal Article · Thu Jul 15 04:00:00 EDT 2021 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2021.01.025· OSTI ID:23200765

Chang, Won Ick ^[1]; Han, Min Guk ^[2]; Kang, Mi Hyun ^[2]; Park, Ji Min ^[2]; Kim, Eric Eunshik; Bae, Junhyung ^[2]; Ahn, Soyeon ^[3]

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1. Department of Radiation Oncology, Seoul National University, School of Medicine, Seoul (Korea, Republic of)
2. Medical Science Research Institute, Seoul National University Bundang Hospital, Seoul (Korea, Republic of)
3. Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seoul (Korea, Republic of)

The poor response of breast cancer to immune checkpoint blockade might result from low immunogenicity and the immune-suppressive tumor microenvironment. We hypothesized that in situ tumor vaccination via radiation therapy (RT) and suppression of immune tolerance via phosphoinositide 3-kinase δ (PI3Kδ) inhibition would enhance the efficacy of immune checkpoint blockade.

• OSTI ID: 23200765
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 3 Vol. 110; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
IMMUNITY
INHIBITION
MAMMARY GLANDS
NEOPLASMS
PHOSPHOTRANSFERASES
RADIOTHERAPY