Overcoming Barriers to Radiopharmaceutical Therapy (RPT): An Overview From the NRG-NCI Working Group on Dosimetry of Radiopharmaceutical Therapy

Journal Article · Mon Mar 15 04:00:00 EDT 2021 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2020.12.002· OSTI ID:23198628

Divgi, Chaitanya ^[1]; Carrasquillo, Jorge A. ^[2]; Meredith, Ruby ^[3]; Seo, Youngho ^[4]; Frey, Eric C. ^[5]; others, and

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1. Divgi Consulting, LLC, Philadelphia (United States)
2. Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York (United States)
3. Department of Radiation Oncology, University of Alabama at Birmingham, Birmingham (United States)
4. Department of Radiology and Biomedical Imaging, University of California, San Francisco (United States)
5. Russell H. Morgan Department of Radiology and Radiologic Science, Johns Hopkins University, School of Medicine, Baltimore (United States)

Radiopharmaceutical therapy (RPT) continues to demonstrate tremendous potential in improving the therapeutic gains in radiation therapy by specifically delivering radiation to tumors that can be well assessed in terms of dosimetry and imaging. Dosimetry in external beam radiation therapy is standard practice. This is not the case, however, in RPT. This NRG (acronym formed from the first letter of the 3 original groups: National Surgical Adjuvant Breast and Bowel Project, the Radiation Therapy Oncology Group, and the Gynecologic Oncology Group)-National Cancer Institute Working Group review describes some of the challenges to improving RPT. The main priorities for advancing the field include (1) developing and adopting best practice guidelines for incorporating patient-specific dosimetry for RPT that can be used at both large clinics with substantial resources and more modest clinics that have limited resources, (2) establishing and improving strategies for introducing new radiopharmaceuticals for clinical investigation, (3) developing approaches to address the radiophobia that is associated with the administration of radioactivity for cancer therapy, and (4) solving the financial and logistical issues of expertise and training in the developing field of RPT.

• OSTI ID: 23198628
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 4 Vol. 109; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
DOSIMETRY
EXTERNAL BEAM RADIATION THERAPY
MAMMARY GLANDS
NEOPLASMS
PATIENTS
RADIOACTIVITY
RADIOPHARMACEUTICALS
RECOMMENDATIONS
SURGERY
TRAINING