miR-199a-5p inhibits the progression of papillary thyroid carcinoma by targeting SNAI1
- Breast Surgery, The Sixth People's Hospital of Ji'nan, 250200 (China)
- Department Two of General Surgery, Yulin First Hospital of Shanxi, 718000 (China)
- Department of General Surgery, Longnan Hospital of Daqing, Heilongjiang, 163453 (China)
Highlights: • miR-199a-5p expression is downregulated in PTC tissues and cells. • miR-199a-5p overexpression suppressed the progression of PTC cells. • SNAI1 is a target of miR-199a-5p and miR-199a-5p suppressed SNAI1 expression in PTC cells. • SNAI1 knockdown inhibited the progression of PTC cells. • miR-199a-5p overexpression hindered tumor growth in PTC in vivo. Increasing evidence has emphasized the important roles of differentially expressed miRNAs in papillary thyroid cancer (PTC) development. miR-199a-5p was previously documented to be downregulated in PTCs compared with normal thyroids. However, the role of miR-199a-5p in the progression of PTC and the underlying mechanism remain to be further addressed.
- OSTI ID:
- 23137318
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 497, Issue 1; Other Information: Copyright (c) 2018 Elsevier Inc. All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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