Salusin-β mediate neuroprotective effects for Parkinson's disease

Journal Article · Sat Sep 15 04:00:00 EDT 2018 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/J.BBRC.2018.07.059· OSTI ID:23134348

Chang, Yujung; Yoo, Junsang; Kim, Hongwon ^[1]; Park, Hi-Joon ^[2]; Jeon, Songhee ^[3]; Kim, Jongpil ^[1]

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1. Laboratory of Stem Cells and Cell Reprogramming, Department of Biomedical Engineering (BK21 plus), Dongguk University, 30, Pildong-ro 1-gil, Jung-gu, Seoul, 04620 (Korea, Republic of)
2. Acupuncture and Meridian Science Research Center, Department of Korean Medical Science, Graduate School of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447 (Korea, Republic of)
3. Department of Biomedical Sciences, Center for Creative Biomedical Scientists, Chonnam National University, Gwangju, 61469 (Korea, Republic of)

Neuropeptides, small peptides found in many mammalian brain, play key roles in communicating with each other to modulate neuronal activity. Here, we reported that endogenous neuropeptide salusin-β has neuroprotective effects on the midbrain dopamine neurons and can be used as an effective therapeutic treatment for Parkinson's disease (PD). We found that the MrgprA1 receptor mediates the neuroprotective effects of salusin-β on the midbrain dopamine neurons. Importantly, intranasal administration of salusin-β in a PD mouse model show the neuroprotection of dopaminergic neurons and increased the survival of midbrain dopamine neurons. Furthermore, inhibition of the salusin-β receptor, MrgprA1, abolished the neuroprotective effects induced by salusin-β. Taken together, these results demonstrate the novel role of salusin-β in the central nervous system and salusin-β can be used as a novel therapeutic to effectively treat PD.

• OSTI ID: 23134348
• Journal Information: Biochemical and Biophysical Research Communications, Journal Name: Biochemical and Biophysical Research Communications Journal Issue: 3 Vol. 503; ISSN BBRCA9; ISSN 0006-291X
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
BRAIN
DOPAMINE
MICE
NERVE CELLS
PEPTIDES