Distinct function of miR-17-92 cluster in the dorsal and ventral adult hippocampal neurogenesis
- Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY, 10065 (United States)
- College of Korean Medicine, Dongguk University, Goyang, 10326 (Korea, Republic of)
- Department of Cell and Developmental Biology, Cornell University Weill Medical College, 1300 York Avenue, New York, NY, 10065 (United States)
Highlights: • miR-17-92 is highly related with hippocampal neurogenesis and mood behavior. • The expression of miR-17-92 cluster is regionally different in hippocampus. • miR-17-92 KO less affect development of neural progenitors in ventral hippocampus. • Interestingly, memory function was not altered by miR-17-92 KO. • These findings suggest the distinct function of regional expression of miR-17-92. It has been known that the dorsal and ventral areas of the dentate gyrus in the hippocampus have distinct roles in memory and mood behaviors. We previously reported that microRNA miR-17-92 regulates adult hippocampal neurogenesis and mood disorders. Here, we suggest that the miR-17-92 cluster is highly expressed in the ventral than the dorsal dentate gyrus in the adult mouse hippocampus. Deletion of miR-17-92 in the adult hippocampus only affects development of neural progenitors in the ventral dentate gyrus, and miR-17-92 knockout mice have no defects in memory functions. Our results suggest that regional expression of miR-17-92 in the dentate gyrus is associated with their distinct functions in hippocampal neurogenesis and related behaviors.
- OSTI ID:
- 23134299
- Journal Information:
- Biochemical and Biophysical Research Communications, Vol. 503, Issue 3; Other Information: Copyright (c) 2018 Elsevier Inc. All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
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