Alpha-mangostin attenuates diabetic nephropathy in association with suppression of acid sphingomyelianse and endoplasmic reticulum stress

Journal Article · Wed Feb 14 23:00:00 EST 2018 · Biochemical and Biophysical Research Communications

DOI:https://doi.org/10.1016/J.BBRC.2018.01.040· OSTI ID:23127420

Liu, Tingting ^[1]; Duan, Wang; Nizigiyimana, Paul; Gao, Lin; Liao, Zhouning; Xu, Boya; Liu, Lerong; Lei, Minxiang ^[1]

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1. Department of Endocrinology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008 (China)

Highlights: • The level of acid sphingomyelinase was increased in diabetic rat kidneys. • ER stress induced apoptosis was increased in diabetic rat kidneys. • Alpha-mangostin alleviated ER stress-induced renal injury. • Alpha-mangostin reduced renal cell apoptosis via inhibiting acid sphingomyelianse. • The work provided a promising method for diabetic nephropathy treatment. Diabetic nephropathy is a common complication of diabetes, but there are currently few treatment options. The aim of this study was to gain insight into the effect of alpha-mangostin on diabetic nephropathy and possible related mechanisms.

• OSTI ID: 23127420
• Journal Information: Biochemical and Biophysical Research Communications, Journal Name: Biochemical and Biophysical Research Communications Journal Issue: 2 Vol. 496; ISSN 0006-291X; ISSN BBRCA9
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
APOPTOSIS
ENDOPLASMIC RETICULUM
KIDNEYS
RATS
STRESSES