FPPS mediates TGF-β1-induced non-small cell lung cancer cell invasion and the EMT process via the RhoA/Rock1 pathway
Journal Article
·
· Biochemical and Biophysical Research Communications
- Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433 (China)
- Department of Respiratory Medicine, Shanghai 10th People's Hospital, Tongji University, Shanghai 200072 (China)
Highlights: • FPPS expression is significantly correlated with TNM stage and metastasis of non-small cell lung cancer. • Inhibition or knockdown of FPPS blocks TGF-β1-induced cell invasion and EMT. • FPPS expression is induced by TGF-β1. • FPPS mediates TGF-β1-induced lung cancer cell invasion and EMT via the RhoA/Rock1 pathway. Farnesyl pyrophosphate synthase (FPPS), a key enzyme in the mevalonate pathway, was recently shown to play a role in cancer progression. However, its role in non-small cell lung cancer (NSCLC) metastasis and the underlying mechanism remain unclear. In this study, FPPS expression was significantly correlated with TNM stage, and metastasis. Inhibition or knockdown of FPPS blocked TGF-β1-induced cell invasion and epithelial-to-mesenchymal transition (EMT) process. FPPS expression of FPPS was induced by TGF-β1 and FPPS promoted cell invasion and EMT via the RhoA/Rock1 pathway. In conclusion, FPPS mediates TGF-β1-induced lung cancer cell invasion and EMT via the RhoA/Rock1 pathway. These findings suggest new treatment strategies to reduce mortality associated with metastasis in patients with NSCLC.
- OSTI ID:
- 23127405
- Journal Information:
- Biochemical and Biophysical Research Communications, Journal Name: Biochemical and Biophysical Research Communications Journal Issue: 2 Vol. 496; ISSN BBRCA9; ISSN 0006-291X
- Country of Publication:
- United States
- Language:
- English
Similar Records
Protective effect of Ac-SDKP on alveolar epithelial cells through inhibition of EMT via TGF-β1/ROCK1 pathway in silicosis in rat
WIP promotes in-vitro invasion ability, anchorage independent growth and EMT progression of A549 lung adenocarcinoma cells by regulating RhoA levels
Celastrol inhibits TGF-β1-induced epithelial–mesenchymal transition by inhibiting Snail and regulating E-cadherin expression
Journal Article
·
Mon Feb 29 23:00:00 EST 2016
· Toxicology and Applied Pharmacology
·
OSTI ID:22687902
WIP promotes in-vitro invasion ability, anchorage independent growth and EMT progression of A549 lung adenocarcinoma cells by regulating RhoA levels
Journal Article
·
Sat Jan 21 23:00:00 EST 2017
· Biochemical and Biophysical Research Communications
·
OSTI ID:22696807
Celastrol inhibits TGF-β1-induced epithelial–mesenchymal transition by inhibiting Snail and regulating E-cadherin expression
Journal Article
·
Fri Aug 09 00:00:00 EDT 2013
· Biochemical and Biophysical Research Communications
·
OSTI ID:22239693