Systemic inflammatory markers associated with cardiovascular disease and acute and chronic exposure to fine particulate matter air pollution (PM2.5) among US NHANES adults with metabolic syndrome

Journal Article · Thu Feb 15 00:00:00 EST 2018 · Environmental Research

DOI:https://doi.org/10.1016/J.ENVRES.2017.11.042· OSTI ID:23100670

Dabass, Arvind; Rager, Judith R. ^[1]; Marsh, Gary M. ^[2]; Venkat, Arvind ^[3]; Holguin, Fernando ^[4]; Sharma, Ravi K. ^[5]

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1. University of Pittsburgh, Graduate School of Public Health, Department of Epidemiology, Pittsburgh, PA (United States)
2. University of Pittsburgh, Graduate School of Public Health, Department of Biostatistics, Pittsburgh, PA (United States)
3. Allegheny Health Network, Department of Emergency Medicine, Pittsburgh, PA (United States)
4. University of Colorado, School of Medicine, Pulmonary Disease and Critical Care Medicine, Aurora, CO (United States)
5. University of Pittsburgh, Graduate School of Public Health, Department of Behavioral and Community Health Sciences, Pittsburgh, PA (United States)

Highlights: • A cross sectional study of the effect of PM{sub 2.5} AP on inflammatory biomarkers among NHANES participants was conducted. • Participants’ Census tract of residence was linked to USEPA downscaler modeled air pollution for the continental US. • Goal was the assessment of susceptibility of adults with metabolic syndrome to PM2.5 exposure and levels of CRP and WBC. • There was a significant effect of PM2.5 at lag day 0; a 10 µg/m3 rise was associated with a 10.1% increase in CRP level. • There were no significant associations with CRP or WBC for those without metabolic syndrome. There has been no investigation to date of adults with metabolic syndrome examining the association of short and long-term exposure to fine particulate matter (PM{sub 2.5}) air pollution with cardiovascular-disease related inflammatory marker (WBC and CRP) levels in a nationally representative sample. The goal of this study is to assess the susceptibility of adults with metabolic syndrome to PM{sub 2.5} exposure as suggested by increased cardiovascular-disease related inflammatory marker levels.

• OSTI ID: 23100670
• Journal Information: Environmental Research, Vol. 161; Other Information: Copyright (c) 2017 Elsevier Inc. All rights reserved.; Country of input: International Atomic Energy Agency (IAEA); ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
AIR POLLUTION
BIOLOGICAL MARKERS
CARDIOVASCULAR DISEASES
CHRONIC EXPOSURE
ENVIRONMENTAL EXPOSURE
INFLAMMATION
PARTICULATES