Association between prenatal bisphenol A and phthalate exposures and fetal metabolic related biomarkers: The Hokkaido study on Environment and Children's Health

Journal Article · Thu Feb 15 04:00:00 EST 2018 · Environmental Research

DOI:https://doi.org/10.1016/J.ENVRES.2017.11.052· OSTI ID:23100669

Minatoya, Machiko; Araki, Atsuko; Miyashita, Chihiro; Ait Bamai, Yu; Itoh, Sachiko ^[1]; Yamamoto, Jun; Onoda, Yu; Ogasawara, Kazuki; Matsumura, Toru ^[2]; Kishi, Reiko ^[1]

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1. Center for Environmental and Health Sciences, Hokkaido University, Kita 12, Nishi 7, Kita-ku, Sapporo 060-0812 (Japan)
2. Institute of Environmental Ecology, Idea Consultants, Inc., 1334-5 Riemon, Yaizu, Shizuoka 421-0212 (Japan)

Highlights: • Early pregnancy exposure to bisphenol A, DBP and DEHP was observed. • Maternal bisphenol A level was negatively associated with cord leptin level. • Early pregnancy exposure to DEHP and DBP may decrease cord leptin levels. Bisphenol A and phthalates are widely detected in human urine, blood, breast milk, and amniotic fluid. Both bisphenol A and phthalates have been suggested as playing a role in obesity epidemics. Exposure to these chemicals during fetal development, and its consequences should be concerning because they can cross the placenta. Thus, this study aimed to assess the association between prenatal exposure to bisphenol A and phthalates, and cord blood metabolic-related biomarkers. Maternal serum was used during the first trimester, to determine prenatal exposure to bisphenol A and phthalates. Levels of metabolic-related biomarkers in the cord blood were also determined. Linear regression models were applied to the 365 participants with both, exposure and biomarker assessments, adjusted for maternal age, pre-pregnancy body mass index, parity, education, and sex of the child. The level of bisphenol A was negatively associated with the leptin level (β = −0.06, 95% confidence interval [CI]: −0.11, −0.01), but was positively associated with the high-molecular-weight adiponectin level, with marginal significance (β = 0.03, 95%CI: 0.00, 0.06). The mono-isobutyl phthalate (MiBP), mono-n-butyl phthalate (MnBP), mono-(2-ethylhexyl) phthalate (MEHP), and summation of MEHP and MECPP to represent DEHP exposure (∑DEHPm) levels were inversely associated with the leptin levels (β=−0.14, 95%CI: −0.27, −0.01; β = −0.12, 95%CI: −0.24, 0.00 with marginal significance; β=0.08, 95%CI: −0.14, −0.03; and β = −0.09, 95%CI: −0.16, −0.03, respectively). The present study provided some evidence that prenatal exposure to bisphenol A and certain phthalates may modify fetal adiponectin and leptin levels.

• OSTI ID: 23100669
• Journal Information: Environmental Research, Journal Name: Environmental Research Vol. 161; ISSN ENVRAL; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
AMNIOTIC FLUID
BIOLOGICAL MARKERS
BLOOD
CHILDREN
DBP
ENVIRONMENT
LEPTIN
MAMMARY GLANDS
METABOLIC DISEASES
MILK
MOLECULAR WEIGHT
PHTHALATES
PLACENTA
PREGNANCY
PRENATAL EXPOSURE
URINE