Upregulated SCUBE2 expression in breast cancer stem cells enhances triple negative breast cancer aggression through modulation of notch signaling and epithelial-to-mesenchymal transition
- Division of Medical Oncology and Hematology, Tri-Service General Hospital, National Defense Medical Centre, Taipei (China)
- Division of Thoracic Surgery, Department of Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City (China)
- Department of Hematology and Oncology, Cancer Center, Taipei Medical University-Shuang Ho Hospital, New Taipei City (China)
- Institute of Biomedical Sciences, Academia Sinica, Taipei (China)
- Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei City (China)
Highlights: • SCUBE2 overexpression enhances the cancer stem cell-like and metastatic phenotypes. • SCUBE2 modulation of the Notch signaling pathway. • SCUBE2 high/ALDH+ TNBC cells exhibit enhanced tumorigenicity in vivo. Metastatic and/or recurrent breast carcinomas are leading causes of cancer-related death worldwide. Breast cancer stem cells (BCSCs) have been implicated in cancer metastases and progression, thus, the need for the discovery and development of effective BCSCs-specific therapies against metastatic and triple negative breast cancer (TNBC). The expression of SCUBE2, originally identified in vascular endothelia, then in several non-endothelial cell types, is downregulated in invasive breast carcinomas. However, the role of SCUBE2 in BCSCs remains unknown. This present study investigated the probable involvements of SCUBE2 in BCSCs and TNBC metastasis.
- OSTI ID:
- 23082637
- Journal Information:
- Experimental Cell Research, Journal Name: Experimental Cell Research Journal Issue: 2 Vol. 370; ISSN 0014-4827; ISSN ECREAL
- Country of Publication:
- United States
- Language:
- English
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