MicroRNA-630 inhibits breast cancer progression by directly targeting BMI1

Journal Article · Mon Jan 15 04:00:00 EST 2018 · Experimental Cell Research

DOI:https://doi.org/10.1016/J.YEXCR.2017.11.039· OSTI ID:23082507

Gong, Xiu-Feng; Yu, An-Lu ^[1]; Tang, Jun ^[2]; Wang, Chen-Long ^[1]; He, Jian-Rong ^[3]; Chen, Guo-Qiang; Zhao, Qian; He, Ming; Zhou, Ci-Xiang ^[1]

---

1. Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai 200025 (China)
2. Institute of Health Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences/Chinese Academy of Sciences & Shanghai Jiao-Tong University School of Medicine (SJTU-SM), Shanghai (China)
3. Department of General Surgery, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025 (China)

Highlights: • MiR-630 initiates apoptosis, blocks cell cycle progression and suppresses cell proliferation in breast cancer cells. • BMI1, a member of polycomb group family, is identified as a novel direct target of miR-630. • BMI1 mediates miR-630-suppressed breast cancer progression including apoptosis induction, cell cycle arrest, and proliferation inhibition. MicroRNAs (miRNAs) play critical roles in breast cancer cell biological processes, including proliferation and apoptosis by inhibiting the expression of their target genes. Herein, we reported that miR-630 overexpression initiates apoptosis, blocks cell cycle progression and suppresses cell proliferation in breast cancer cells. Furthermore, BMI1, a member of polycomb group family, was identified as a direct target of miR-630, and there was a negative correlation between the expression levels of BMI1 and miR-630 in human breast cancer samples. With a series of biology approaches, subsequently, we proved that BMI1 was a functional downstream target of miR-630 and mediated the property of miR-630-dependent inhibition of breast cancer progression. Taken together, these findings provide further evidence on the tumor-suppression function of miR-630 in breast cancer, and clarify BMI1 as a novel functional target gene of miR-630.

• OSTI ID: 23082507
• Journal Information: Experimental Cell Research, Journal Name: Experimental Cell Research Journal Issue: 2 Vol. 362; ISSN 0014-4827; ISSN ECREAL
• Country of Publication: United States
• Language: English

Related Subjects

60 APPLIED LIFE SCIENCES
APOPTOSIS
CELL CYCLE
CELL PROLIFERATION
HUMAN POPULATIONS
MAMMARY GLANDS
NEOPLASMS