Development and Preliminary Evaluation of a Murine Model of Chronic Radiation-Induced Proctitis

Journal Article · Wed Aug 15 04:00:00 EDT 2018 · International Journal of Radiation Oncology, Biology and Physics

DOI:https://doi.org/10.1016/J.IJROBP.2018.04.061· OSTI ID:23065535

Ashcraft, Kathleen A.; Miles, Devin ^[1]; Sunday, Mary E. ^[2]; Choudhury, Kingshuk Roy ^[3]; Young, Kenneth H. ^[1]; others, and

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1. Duke University School of Medicine, Department of Radiation Oncology, Durham, North Carolina (United States)
2. Duke University School of Medicine, Department of Pathology, Durham, North Carolina (United States)
3. Duke University School of Medicine Department of Biostatistics and Bioinformatics, Durham, North Carolina (United States)

Radiotherapy (RT) is commonly used to treat most pelvic malignancies. While treatment is often effective, curative radiation doses to the rectum can result in chronic radiation-induced proctitis, which is characterized by diarrhea, tenesmus, and/or rectal bleeding, recently termed pelvic radiation disease. An animal model of chronic radiation-induced proctitis would be useful to test both preventative and therapeutic strategies to limit this morbidity but has been elusive because of the high rodent mortality associated with acute bowel RT injury. The objective of this research was to develop a novel mouse model of chronic radiation-induced proctitis using advanced technology.

• OSTI ID: 23065535
• Journal Information: International Journal of Radiation Oncology, Biology and Physics, Journal Name: International Journal of Radiation Oncology, Biology and Physics Journal Issue: 5 Vol. 101; ISSN IOBPD3; ISSN 0360-3016
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
DIARRHEA
DISEASE INCIDENCE
MICE
MORTALITY
NEOPLASMS
PROCTITIS
RADIATION DOSES
RADIOTHERAPY
RECTUM